Product image of L-Thyroxin Levothyroxin-Natrium Henning (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin Levothyroxin-Natrium Henning

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin Levothyroxin-Natrium Henning (Levothyroxine Sodium)

Levothyroxine, the active ingredient in L-Thyroxin Levothyroxin-Natrium Henning, is a thyroid hormone presented as an oral tablet for oral use. It replaces deficient thyroid hormone and is used to treat hypothyroidism, goiter, and other conditions requiring thyroid hormone replacement.

GNH India supplies L-Thyroxin Levothyroxin-Natrium Henning as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Levothyroxine sodium is used to manage disorders of thyroid hormone deficiency and related conditions.

  • Hypothyroidism: restores normal thyroid hormone levels and alleviates symptoms such as fatigue and weight gain.
  • Goiter: reduces thyroid gland enlargement by normalizing hormone feedback.
  • Thyroid hormone replacement: provides a synthetic source of T4 for patients after thyroidectomy or radioactive iodine therapy.

How It Works

  • Levothyroxine is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. The hormone binds nuclear thyroid hormone receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth, thereby normalizing systemic thyroid hormone activity.

Side Effects

Levothyroxine may cause a range of adverse reactions, most of which are dose‑related and reversible upon adjustment.

Common Side Effects

  • Palpitations: feeling of rapid or irregular heartbeat.
  • Nervousness: heightened anxiety or jitteriness.
  • Weight loss: unintended decrease in body weight.
  • Heat intolerance: increased sensitivity to warm environments.
  • Diarrhea: loose, frequent stools.
  • Menstrual irregularities: changes in cycle length or flow.

Serious or Rare Side Effects

  • Cardiac arrhythmia: potentially life‑threatening irregular heart rhythm.
  • Osteoporosis: decreased bone mineral density with long‑term excess.
  • Myocardial infarction: increased risk in susceptible patients.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hyperthyroidism symptoms: tremor, insomnia, or excessive sweating.
  • Acute adrenal insufficiency: adrenal crisis in patients with concurrent adrenal disease.

Precautions & Warnings

Levothyroxine therapy requires careful monitoring and patient education.

  • Dose adjustment: titrate based on thyroid function tests and clinical response.
  • Cardiovascular disease: use caution in patients with angina, arrhythmias, or recent myocardial infarction.
  • Pregnancy and lactation: assess risk‑benefit; dosage may need modification.
  • Drug interactions: review concomitant medications that affect absorption or metabolism.
  • Monitoring: schedule regular TSH and free T4 assessments.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levothyroxine can interact with several medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Levothyroxine + antacids containing aluminum or magnesium: reduces absorption.
  • Levothyroxine + levothyroxine‑binding agents (e.g., sucralfate): markedly decreases bioavailability.
  • Levothyroxine + glucocorticoids (high dose): may require higher levothyroxine dose.
  • Levothyroxine + amiodarone: can cause thyroid dysfunction.
  • Levothyroxine + warfarin: may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Levothyroxine + cholesterol‑lowering agents (e.g., cholestyramine): may lower levothyroxine levels.
  • Levothyroxine + oral contraceptives or hormone replacement therapy: may increase levothyroxine requirement.
  • Levothyroxine + selective serotonin reuptake inhibitors (SSRIs): monitor for mood changes.
  • Levothyroxine + beta‑blockers: may mask tachycardia symptoms.
  • Levothyroxine + iron supplements: decrease absorption; separate dosing by at least 4 hours.

Frequently Asked Questions

L-Thyroxin Levothyroxin-Natrium contains levothyroxine sodium, a synthetic thyroid hormone used to treat hypothyroidism, manage goiter, and provide thyroid hormone replacement after thyroidectomy or radioactive iodine therapy. It restores normal hormone levels, improving metabolic function and alleviating related symptoms.

Levothyroxine is a synthetic form of thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. T3 binds nuclear thyroid hormone receptors, regulating gene expression that controls basal metabolic rate, protein synthesis, and growth, thereby normalizing systemic thyroid activity.

The appropriate levothyroxine dose is individualized and determined by the prescribing clinician based on the patient’s age, weight, severity of thyroid deficiency, and laboratory results (TSH and free T4). Dosage adjustments are made during follow‑up to achieve optimal thyroid hormone levels.

Levothyroxine is generally considered safe in pregnancy and lactation when medically indicated, as untreated hypothyroidism can harm both mother and fetus. Dosage may need adjustment during pregnancy. Breastfeeding mothers should consult their healthcare provider to ensure appropriate dosing for both mother and infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will respond with pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levothyroxine provides a synthetic form of T4, the primary hormone produced by the thyroid gland, and is the standard of care for most hypothyroid patients. Alternatives such as liothyronine (synthetic T3) or combination T4/T3 therapy may be used in specific cases, but levothyroxine offers a stable, once‑daily dosing regimen with a well‑established safety profile.

Levothyroxine tablets should be stored below 25 °C in their original container, protected from moisture, heat, and direct sunlight. Keep the packaging tightly closed and avoid exposure to humidity to maintain tablet integrity and potency throughout its shelf life.

Levothyroxine is taken orally, usually in tablet form, on an empty stomach 30‑60 minutes before breakfast. Swallow the tablet whole with a glass of water; do not crush or chew it, as this may affect absorption. Follow the prescribing clinician’s instructions regarding timing and dosage.

Serious risks include cardiac arrhythmias, myocardial infarction, severe osteoporosis, and signs of overt hyperthyroidism such as tremor, insomnia, and heat intolerance. Patients with pre‑existing heart disease, osteoporosis, or adrenal insufficiency require close monitoring and possible dose adjustments to mitigate these risks.

Levothyroxine is contraindicated in patients with known hypersensitivity to levothyroxine sodium or any of its excipients. Caution is advised for individuals with untreated adrenal insufficiency, acute myocardial infarction, or uncorrected thyrotoxicosis, as the drug may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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