Product image of L-Thyroxin-Na Abz (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin-Na Abz

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin-Na Abz (Levothyroxine Sodium)

Levothyroxine Sodium, the active ingredient in L-Thyroxin-Na Abz, is a synthetic thyroid hormone presented as a tablet for oral use. It treats hypothyroidism and is used for thyroid hormone replacement after thyroidectomy or in goiter patients.

GNH India supplies L-Thyroxin-Na Abz as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Abz-Pharma Gmbh

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Indications & Clinical Uses

Levothyroxine Sodium is a synthetic thyroid hormone used to replace deficient endogenous hormone in disorders of thyroid function.

  • Hypothyroidism: restores normal thyroid hormone levels and alleviates symptoms such as fatigue and weight gain.
  • Post‑thyroidectomy thyroid hormone replacement: provides necessary hormone after surgical removal of the thyroid gland.
  • Goiter: helps normalize thyroid hormone production and can reduce gland enlargement.

How It Works

  • Levothyroxine Sodium is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption it is converted in peripheral tissues to the active hormone triiodothyronine (T3). Both T4 and T3 bind to nuclear thyroid hormone receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth.

Side Effects

Levothyroxine Sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild headache reported in some patients.
  • Fatigue: transient tiredness during dose adjustment.
  • Weight loss: unintended loss of weight.
  • Palpitations: occasional heart‑beat sensations.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm, especially in high doses.
  • Angina: chest pain due to reduced coronary blood flow.
  • Hyperthyroidism symptoms: tremor, heat intolerance, anxiety.
  • Bone loss: increased risk of osteoporosis with long‑term overtreatment.
  • Allergic reaction: rash, itching, or swelling.

Precautions & Warnings

When prescribing Levothyroxine Sodium, clinicians should consider several safety precautions to minimize risks.

  • Dose titration: adjust dose gradually based on thyroid function tests.
  • Cardiovascular monitoring: assess heart disease history before initiating therapy.
  • Pregnancy considerations: use only if benefits outweigh potential risks.
  • Drug interactions: review concomitant medications that affect absorption or metabolism.
  • Elderly patients: start with lower doses and monitor for overtreatment.
  • Store at ambient temperature: keep tablets below 25 °C in the original container, protected from moisture.

Avoid Interactions

Levothyroxine Sodium can interact with various medicines, altering its absorption or activity.

Major Interactions (Avoid)

  • Calcium or iron supplements: bind levothyroxine in the gut, reducing absorption.
  • Proton pump inhibitors: may decrease levothyroxine bioavailability.
  • Antacids containing aluminum or magnesium: interfere with absorption.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., sertraline): may affect thyroid hormone levels.
  • Anticoagulants (e.g., warfarin): levothyroxine can enhance anticoagulant effect.
  • Cholesterol‑lowering agents (e.g., cholestyramine): decrease levothyroxine absorption.
  • Diabetes medications: thyroid status influences glucose control.

Frequently Asked Questions

L-Thyroxin-Na Abz contains levothyroxine sodium, a synthetic thyroid hormone used to treat hypothyroidism, to provide hormone replacement after thyroidectomy, and to manage goiter by normalising thyroid hormone levels.

Levothyroxine sodium is a synthetic form of thyroxine (T4). After oral absorption it is converted to the active hormone triiodothyronine (T3) in peripheral tissues, where it binds nuclear thyroid receptors and regulates gene expression that controls metabolism and growth.

The appropriate dose of levothyroxine is individualized. A prescriber determines the exact amount based on the patient’s age, weight, thyroid function tests, and clinical response, and then provides specific dosing instructions.

Levothyroxine is generally considered safe in pregnancy when the benefits outweigh potential risks, as untreated hypothyroidism can harm both mother and fetus. Limited data exist for breastfeeding, but it is usually compatible; clinicians should monitor thyroid status closely.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Levothyroxine sodium is the standard synthetic thyroid hormone, offering consistent potency and predictable absorption compared with natural desiccated thyroid extracts, which contain variable amounts of T4 and T3. Most clinicians prefer levothyroxine for precise dose titration.

Store the tablets at ambient temperature, preferably below 25 °C, in the original packaging to protect from moisture and light. Keep out of reach of children and avoid exposing the product to extreme heat or humidity.

L-Thyroxin-Na Abz is taken orally, usually on an empty stomach 30‑60 minutes before breakfast. The tablet should be swallowed whole with a glass of water and not crushed or chewed.

Serious risks include cardiac arrhythmias, angina, and symptoms of overt hyperthyroidism such as tremor, anxiety, and heat intolerance. Long‑term overtreatment can also increase the risk of osteoporosis, especially in post‑menopausal women.

Patients with untreated adrenal insufficiency, acute myocardial infarction, or known hypersensitivity to levothyroxine should avoid the product. It is also contraindicated in individuals with uncorrected thyrotoxicosis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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