Product image of L-Thyroxin-Na Ct (Levothyroxine Sodium) supplied by GNH India

L-Thyroxin-Na Ct

Active Ingredient:
Levothyroxine Sodium
Origin:
EU

L-Thyroxin-Na Ct (Levothyroxine Sodium)

Levothyroxine Sodium, the active ingredient in L-Thyroxin-Na Ct, is a thyroid hormone presented as an oral tablet for oral use. It treats hypothyroidism and related thyroid hormone deficiencies in adults and children, helping to normalize metabolic processes.

GNH India supplies L-Thyroxin-Na Ct as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU manufacturing standards and is distributed under strict quality controls. GNH India ensures batch‑to‑batch consistency through validated analytical methods.

Manufacturer / TM Owner

Abz-Pharma Gmbh

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Indications & Clinical Uses

Levothyroxine Sodium is used to replace deficient thyroid hormone in conditions affecting the hypothalamic‑pituitary‑thyroid axis.

  • Hypothyroidism: restores normal thyroid hormone levels, improving metabolism and symptom control.
  • Thyroid hormone deficiency: provides exogenous T4 to compensate for inadequate endogenous production.
  • Goiter: reduces thyroid‑stimulating hormone stimulation, helping to decrease gland enlargement.

How It Works

  • Levothyroxine Sodium is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active hormone triiodothyronine (T3) in peripheral tissues. The resulting increase in circulating thyroid hormone binds nuclear thyroid hormone receptors, regulating gene transcription that controls basal metabolic rate, protein synthesis, and growth. By restoring physiological hormone concentrations, it normalizes the feedback loop of the hypothalamic‑pituitary‑thyroid axis.

Side Effects

Levothyroxine Sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild headache reported in some patients.
  • Insomnia: difficulty sleeping, especially after dose adjustments.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Heat intolerance: increased sensitivity to warm temperatures.
  • Tremor: fine shaking of hands or limbs.
  • Weight loss: unintended reduction in body weight.

Serious or Rare Side Effects

  • Cardiac arrhythmia: potentially life‑threatening irregular heart rhythm.
  • Angina pectoris: chest pain due to reduced coronary blood flow.
  • Myocardial infarction: heart attack in susceptible individuals.
  • Bone loss: accelerated osteoporosis with long‑term overtreatment.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Adrenal crisis: precipitated in patients with adrenal insufficiency.

Precautions & Warnings

When prescribing Levothyroxine Sodium, clinicians should consider several safety measures to minimize risks.

  • Dose titration in elderly: start with lower doses and adjust gradually.
  • Monitor thyroid function tests: check TSH and free T4 regularly to maintain target range.
  • Cardiovascular disease caution: evaluate heart condition before initiating therapy.
  • Interact with pregnancy: assess risk‑benefit, adjust dose as needed under medical supervision.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypothyroidism.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Levothyroxine Sodium can interact with several medicines, altering its absorption or therapeutic effect.

Major Interactions (Avoid)

  • Antacids (aluminum, magnesium): significantly reduce levothyroxine absorption.
  • Calcium supplements: bind levothyroxine in the gut, decreasing bioavailability.
  • Iron preparations: interfere with absorption, requiring separation of dosing times.

Moderate Interactions (Monitor Closely)

  • Warfarin: levothyroxine may enhance anticoagulant effect, requiring INR monitoring.
  • Amiodarone: can alter thyroid hormone metabolism, necessitating thyroid function monitoring.

Frequently Asked Questions

L-Thyroxin-Na Ct contains levothyroxine sodium, a synthetic thyroid hormone prescribed to replace deficient endogenous hormone in patients with hypothyroidism, thyroid hormone deficiency, or goiter, helping to restore normal metabolic function.

Levothyroxine sodium is a synthetic form of thyroxine (T4). After oral absorption it is converted to the active hormone triiodothyronine (T3) in peripheral tissues, binds nuclear thyroid receptors, and regulates gene transcription that controls basal metabolism, growth, and protein synthesis, thereby normalizing the hypothalamic‑pituitary‑thyroid feedback loop.

The appropriate dose of L-Thyroxin-Na Ct is individualized and determined by the prescribing healthcare professional based on the patient’s age, weight, severity of thyroid deficiency, and laboratory results such as TSH and free T4 levels.

Levothyroxine is generally considered the treatment of choice for hypothyroidism in pregnancy because adequate maternal thyroid hormone is essential for fetal development. However, dosing may need adjustment and should be managed by a qualified clinician. Limited data are available for breastfeeding, and a prescriber should evaluate risks and benefits.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levothyroxine sodium is the standard synthetic T4 formulation and is bioequivalent to other branded levothyroxine products. Compared with combination T4/T3 preparations, it provides a stable, once‑daily source of T4 that the body converts to T3 as needed, offering a predictable pharmacokinetic profile.

L-Thyroxin-Na Ct should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture, heat and direct light. Do not store in the bathroom or near a kitchen sink to maintain product stability.

The medication is taken orally, usually on an empty stomach, at least 30 minutes before breakfast or other medications. The tablet should be swallowed whole with a full glass of water; it should not be crushed, chewed, or divided unless instructed by a healthcare professional.

Serious adverse events include cardiac arrhythmias, angina, myocardial infarction, severe osteoporosis from overtreatment, and allergic reactions such as anaphylaxis. Patients with pre‑existing heart disease or adrenal insufficiency require careful monitoring and dose adjustments.

Levothyroxine should be avoided in individuals with untreated adrenal insufficiency, uncorrected thyrotoxicosis, or known hypersensitivity to levothyroxine sodium or any excipients in the tablet. Clinicians should also exercise caution in patients with recent myocardial infarction or severe cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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