Product image of Labdiazina (Sulfadiazine) supplied by GNH India

Labdiazina

Active Ingredient:
Sulfadiazine
Origin:
EU

Labdiazina (Sulfadiazine)

Sulfadiazine, the active ingredient in Labdiazina, is a sulfonamide antibiotic presented as an oral formulation for oral use. It acts against susceptible bacteria to treat urinary tract infections, serve as prophylaxis for meningitis, and manage otitis media in patients for whom this class of agents is appropriate.

GNH India supplies Labdiazina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring product quality through stringent manufacturing and regulatory standards. The company provides reliable logistics and documentation for global distribution.

Manufacturer / TM Owner

Sidefarma - Sociedade Industrial De Expansão Farmacêutica, S.A.

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Indications & Clinical Uses

  • Labdiazina (sulfadiazine) is used in bacterial infections where inhibition of folic acid synthesis is therapeutic.
  • Urinary tract infections: reduces bacterial growth to resolve infection in the urinary system.
  • Meningitis prophylaxis: prevents meningococcal infection in high‑risk exposures.
  • Otitis media: treats middle‑ear bacterial infection to alleviate symptoms and prevent complications.

How It Works

  • Sulfadiazine inhibits bacterial dihydropteroate synthase, a key enzyme in the folic acid synthesis pathway. By blocking the conversion of para‑aminobenzoic acid (PABA) to dihydropteroic acid, it prevents the production of tetrahydrofolic acid, a cofactor essential for nucleic acid synthesis, thereby inhibiting bacterial growth and replication.

Side Effects

Sulfadiazine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea or vomiting
  • Skin rash or mild itching
  • Headache
  • Diarrhea
  • Photosensitivity to sunlight
  • Mild fever

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Agranulocytosis or severe leukopenia
  • Hepatic dysfunction or jaundice
  • Acute renal impairment
  • Severe hypersensitivity reactions including anaphylaxis
  • Hemolytic anemia in susceptible individuals

Precautions & Warnings

  • When prescribing Labdiazina, clinicians should consider several safety measures.
  • Renal function: adjust use in patients with impaired renal function.
  • Hepatic function: monitor liver enzymes during therapy.
  • Allergy: avoid in patients with known sulfonamide hypersensitivity.
  • Pregnancy: use only if potential benefits justify potential risks.
  • Drug monitoring: perform complete blood count for prolonged treatment.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Sulfadiazine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
  • Methotrexate: can increase methotrexate toxicity.
  • Phenytoin: may reduce phenytoin levels, compromising seizure control.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce contraceptive efficacy.
  • Lithium: can increase lithium serum concentrations, risking toxicity.

Frequently Asked Questions

Labdiazina contains sulfadiazine, a sulfonamide antibiotic indicated for treating urinary tract infections, providing prophylaxis against meningitis, and managing bacterial otitis media. It is prescribed when a clinician determines that a sulfonamide is appropriate for the identified infection.

Sulfadiazine blocks the bacterial enzyme dihydropteroate synthase, which is essential for folic acid synthesis. By preventing the formation of tetrahydrofolic acid, the drug inhibits nucleic acid production, limiting bacterial growth and allowing the immune system to clear the infection.

The dosage of Labdiazina is individualized by the prescribing clinician based on the infection type, severity, patient age, weight, and renal function. No fixed regimen is provided here; the prescriber determines the appropriate dose and schedule.

Safety data for sulfadiazine in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant. Healthcare providers should discuss risks and alternatives with the patient.

To order Labdiazina, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Labdiazina (sulfadiazine) shares the same class mechanism as other sulfonamides such as sulfamethoxazole, but its pharmacokinetic profile and spectrum differ slightly. Compared with trimethoprim‑sulfamethoxazole, sulfadiazine lacks the synergistic trimethoprim component, which may affect efficacy against certain organisms and influence dosing considerations.

Labdiazina should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight and excessive heat. Ensure the packaging remains sealed until use to maintain product stability.

Labdiazina is administered orally, usually with a full glass of water. It may be taken with or without food, depending on the prescriber's advice. Patients should follow the dosing schedule provided by their healthcare professional and complete the full course of therapy.

Serious adverse reactions include severe skin disorders such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, blood dyscrasias like agranulocytosis, hepatic injury, renal impairment, and life‑threatening hypersensitivity reactions. Prompt medical attention is required if any of these symptoms develop.

Labdiazina is contraindicated in patients with a known hypersensitivity to sulfonamides, severe renal or hepatic impairment, or those who have experienced severe adverse reactions to related drugs. Caution is also advised for patients with certain blood disorders or immune deficiencies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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