Product image of Labentrol (Ciprofloxacin) supplied by GNH India

Labentrol

Active Ingredient:
Ciprofloxacin
Origin:
EU

Labentrol (Ciprofloxacin)

Ciprofloxacin, the active ingredient in Labentrol, is a fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats a broad range of bacterial infections in adult and pediatric patients when prescribed by a healthcare professional.

GNH India supplies Labentrol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sja Pharm Ltd

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Indications & Clinical Uses

Ciprofloxacin is a fluoroquinolone antibiotic that targets bacterial DNA replication, making it effective for several infection types.

  • Urinary tract infection: eradicates susceptible Gram‑negative bacteria causing uncomplicated cystitis.
  • Respiratory tract infection: treats acute exacerbations of chronic bronchitis and community‑acquired pneumonia.
  • Skin and soft‑tissue infection: combats susceptible Staphylococcus and Streptococcus species.
  • Gastrointestinal infection: effective against travel‑related diarrheal disease caused by susceptible organisms.
  • Bone and joint infection: used for osteomyelitis caused by susceptible bacteria.

How It Works

  • Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents DNA synthesis and cell division, leading to bacterial cell death. This bactericidal action is concentration‑dependent and effective against a wide spectrum of Gram‑negative and some Gram‑positive organisms.

Side Effects

Common side effects are generally mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, occasionally watery.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Rash: mild skin erythema.
  • Photosensitivity: increased sunburn risk.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, may occur without warning.
  • Peripheral neuropathy: numbness or tingling in extremities.
  • Clostridioides difficile infection: severe colitis.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • QT interval prolongation: cardiac rhythm disturbances.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.

Precautions & Warnings

Ciprofloxacin requires careful use in certain populations and conditions.

  • Renal impairment: dose adjustment may be needed.
  • History of tendon disorders: avoid use due to risk of tendon rupture.
  • Concomitant corticosteroid therapy: increased risk of tendon injury.
  • Cardiac conditions: monitor for QT prolongation.
  • Pregnancy and breastfeeding: safety not established; use only if clearly needed.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ciprofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce ciprofloxacin absorption.
  • Iron supplements: significantly decrease drug bioavailability.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Cyclosporine: increased cyclosporine levels leading to toxicity.
  • Theophylline: elevated plasma concentrations causing toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: heightened risk of central nervous system stimulation.
  • Corticosteroids: additive risk of tendon rupture.
  • Diabetic agents: potential for hypoglycemia.
  • Oral hypoglycemics: may require dose adjustment.
  • Certain antiarrhythmics: monitor QT interval.

Frequently Asked Questions

Labentrol contains ciprofloxacin, which is prescribed for a range of bacterial infections such as urinary tract infections, respiratory tract infections, skin and soft‑tissue infections, gastrointestinal infections, and bone or joint infections caused by susceptible organisms.

Ciprofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes needed for DNA replication and cell division. By inhibiting these targets, it stops bacterial growth and leads to bacterial cell death, providing a bactericidal effect against many Gram‑negative and some Gram‑positive bacteria.

The dosage of Labentrol is determined by the prescribing clinician based on the specific infection, patient age, weight, renal function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

The safety of ciprofloxacin in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit outweighs any possible risk, and the decision must be made by a qualified healthcare provider.

To request Labentrol, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Labentrol (ciprofloxacin) offers a broad spectrum of activity against many Gram‑negative pathogens and some Gram‑positive organisms, similar to other fluoroquinolones. Its pharmacokinetic profile, dosing convenience, and established clinical data make it a widely used option, though choice of agent depends on infection type, resistance patterns, and patient-specific factors.

Labentrol should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its stability and potency.

Labentrol is taken orally, usually as a tablet, with or without food as directed by the prescriber. The tablet should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed.

Serious risks include tendon rupture (especially the Achilles tendon), peripheral neuropathy, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, QT interval prolongation, and hepatic toxicity. Patients should seek immediate medical attention if they experience sudden tendon pain, numbness, severe rash, or cardiac symptoms.

Labentrol is contraindicated in patients with a known hypersensitivity to ciprofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals with certain cardiac conditions that predispose them to QT prolongation. It should also be used with caution in patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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