Product image of Labetalol Hcl Mylan (Labetalol Hydrochloride) supplied by GNH India

Labetalol Hcl Mylan

Active Ingredient:
Labetalol Hydrochloride
Origin:
EU

Labetalol Hcl Mylan (Labetalol Hydrochloride)

Labetalol Hydrochloride, the active ingredient in Labetalol Hcl Mylan, is a non‑selective beta blocker with alpha‑1 antagonist activity presented as an oral tablet for oral use. It treats hypertension and hypertensive emergencies in adult patients.
GNH India supplies Labetalol Hcl Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan B.V.

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Indications & Clinical Uses

Labetalol Hydrochloride is used to manage conditions involving elevated blood pressure and related cardiovascular stress.

  • Hypertension: lowers systemic blood pressure in patients with essential hypertension.
  • Hypertensive emergencies: provides rapid blood pressure control in acute, severe hypertension.
  • Aortic dissection: helps achieve target blood pressure to reduce shear stress on the aortic wall.

How It Works

  • Labetalol Hydrochloride blocks alpha‑1 adrenergic receptors and non‑selective beta‑adrenergic receptors, reducing peripheral vascular resistance and decreasing cardiac output. The combined alpha‑ and beta‑blockade leads to a net reduction in systemic blood pressure without significant reflex tachycardia, making it effective for both chronic hypertension and acute hypertensive crises.

Side Effects

Labetalol may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after dose initiation.
  • Fatigue: generalized tiredness or lack of energy.
  • Headache: mild to moderate pain in the head region.
  • Nausea: feeling of stomach upset or urge to vomit.

Serious or Rare Side Effects

  • Bronchospasm: tightening of airway muscles, particularly in patients with asthma.
  • Severe hypotension: dangerously low blood pressure requiring medical attention.
  • Hepatic dysfunction: abnormal liver enzyme elevations or hepatitis.
  • Cardiac conduction abnormalities: heart block or severe bradycardia.

Precautions & Warnings

Before prescribing Labetalol, clinicians should consider several safety measures.

  • Blood pressure monitoring: regularly check to avoid excessive hypotension.
  • Asthma or COPD: use with caution as beta‑blockade may worsen bronchospasm.
  • Abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Liver impairment: adjust dosing and monitor hepatic function.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Labetalol can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Other antihypertensives (e.g., clonidine): may cause profound hypotension.
  • Calcium channel blockers (verapamil): additive blood pressure lowering effect.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive response.
  • Diuretics: can enhance electrolyte disturbances.
  • Antidiabetic agents: may mask hypoglycemia symptoms.

Frequently Asked Questions

Labetalol Hcl Mylan contains Labetalol Hydrochloride, which is prescribed to lower high blood pressure in patients with hypertension and to provide rapid blood pressure control during hypertensive emergencies. It may also be used in specific situations such as aortic dissection where swift blood pressure reduction is needed.

Labetalol Hydrochloride works by simultaneously blocking alpha‑1 adrenergic receptors, which relaxes blood vessels, and non‑selective beta‑adrenergic receptors, which reduces heart rate and cardiac output. This dual action decreases peripheral resistance and overall blood pressure.

The appropriate dose of Labetalol Hcl Mylan is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of Labetalol Hydrochloride in pregnancy and lactation has not been definitively established. Healthcare providers will weigh potential benefits against possible risks before prescribing it to pregnant or nursing individuals. Patients should discuss any concerns with their doctor.

To order Labetalol Hcl Mylan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Labetalol’s unique combination of alpha‑1 and non‑selective beta‑blockade differentiates it from agents that target only one receptor type. This dual mechanism can provide more balanced blood pressure reduction, especially in acute settings, whereas many other antihypertensives act solely on either the vascular tone or heart rate.

Labetalol Hcl Mylan should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Labetalol Hcl Mylan is taken orally, usually as a tablet. The exact dosing schedule, including the number of tablets and timing, is prescribed by a qualified healthcare professional and should be followed exactly as directed.

Serious risks include severe hypotension, bronchospasm in patients with reactive airway disease, hepatic dysfunction, and cardiac conduction abnormalities such as heart block or marked bradycardia. Patients should seek immediate medical attention if they experience symptoms like extreme dizziness, difficulty breathing, or fainting.

Labetalol is contraindicated in individuals with known hypersensitivity to labetalol or any component of the formulation, severe asthma or chronic obstructive pulmonary disease, and in patients with second‑ or third‑degree heart block without a pacemaker. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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