Product image of Labetalol Tillomed (Labetalol Hydrochloride) supplied by GNH India

Labetalol Tillomed

Active Ingredient:
Labetalol Hydrochloride
Origin:
EU

Labetalol Tillomed (Labetalol Hydrochloride)

Labetalol Hydrochloride, the active ingredient in Labetalol Tillomed, is a beta blocker (mixed alpha‑1 and non‑selective beta‑adrenergic antagonist) presented as an oral dosage form for oral use. It is employed to lower blood pressure in patients with hypertension and to manage hypertensive emergencies.
GNH India supplies Labetalol Tillomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tillomed Laboratories Ltd

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Indications & Clinical Uses

  • Labetalol Tillomed is a mixed‑alpha and beta‑adrenergic blocker used in cardiovascular conditions.
  • Hypertension: reduces systemic blood pressure for long‑term control.
  • Hypertensive emergencies: provides rapid blood pressure reduction in acute crises.
  • Post‑operative hypertension: helps stabilize blood pressure after surgical procedures.

How It Works

  • Labetalol blocks alpha‑1 adrenergic receptors, causing vasodilation, and simultaneously antagonizes non‑selective beta‑adrenergic receptors, decreasing heart rate and myocardial contractility. The combined effect lowers peripheral vascular resistance and cardiac output, resulting in reduced arterial pressure.

Side Effects

Labetalol may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness or light‑headedness
  • Fatigue or weakness
  • Headache
  • Nausea or abdominal discomfort
  • Nasal congestion
  • Tremor

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Acute heart failure
  • Hepatic dysfunction
  • Bronchospasm in asthmatic patients
  • Hypotension leading to syncope

Precautions & Warnings

  • Before prescribing Labetalol, clinicians should consider several safety measures.
  • Assess cardiovascular status: evaluate for existing heart block or severe bradycardia.
  • Monitor liver function: avoid in patients with significant hepatic impairment.
  • Review asthma history: beta‑blockade may exacerbate bronchospasm.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension.
  • Pregnancy and lactation: use only if benefits outweigh risks.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Labetalol can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: additive bradycardia and hypotension.
  • Calcium channel blockers (e.g., verapamil, diltiazem): risk of severe heart block.
  • Clonidine withdrawal: may precipitate hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: may mask hypoglycaemia symptoms.
  • NSAIDs: can reduce antihypertensive effect.
  • MAO inhibitors: potential for hypertensive episodes.
  • Antidepressants (tricyclics): increased risk of cardiac arrhythmias.

Frequently Asked Questions

Labetalol Tillomed is an oral antihypertensive medication used to lower blood pressure in patients with chronic hypertension and to provide rapid control during hypertensive emergencies. It may also be employed to manage postoperative hypertension when swift blood pressure stabilization is required.

Labetalol Hydrochloride blocks alpha‑1 adrenergic receptors, causing vasodilation, and simultaneously antagonizes non‑selective beta‑adrenergic receptors, reducing heart rate and contractility. The combined actions decrease peripheral vascular resistance and cardiac output, leading to lowered arterial pressure.

The appropriate dose of Labetalol Tillomed is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made according to clinical guidelines and individual therapeutic needs.

Safety of Labetalol in pregnancy or while breastfeeding has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Labetalol Tillomed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Labetalol’s unique dual action on alpha‑1 and beta receptors distinguishes it from pure beta‑blockers or calcium‑channel blockers. This profile offers effective blood pressure reduction with added vasodilatory benefit, making it useful in situations where rapid control is needed, such as hypertensive emergencies.

Labetalol Tillomed should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Labetalol Tillomed is taken orally, usually with or without food, as directed by the prescribing clinician. The tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe bradycardia, heart block, acute heart failure, and marked hypotension that can lead to syncope. Patients should be monitored for signs of these conditions, especially during dose titration or when combined with other cardiovascular agents.

Labetalol is contraindicated in patients with known hypersensitivity to labetalol or any component of the formulation, severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and uncompensated heart failure. Caution is also advised in individuals with asthma or severe liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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