Product image of Labetalol Tillomed Laboratories (Labetalol Hydrochloride) supplied by GNH India

Labetalol Tillomed Laboratories

Active Ingredient:
Labetalol Hydrochloride
Origin:
EU

Labetalol Tillomed Laboratories (Labetalol Hydrochloride)

Labetalol Hydrochloride, the active ingredient in Labetalol Tillomed Laboratories, is a beta‑adrenergic blocker with alpha‑1 blocking activity presented as an oral formulation for oral use. It is employed to treat essential hypertension, hypertensive emergencies, and hypertension associated with pheochromocytoma in adult patients.
GNH India supplies Labetalol Tillomed Laboratories as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tillomed Laboratories Ltd

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Indications & Clinical Uses

Labetalol is indicated for conditions affecting the cardiovascular system where blood pressure control is required.

  • Essential hypertension: lowers systolic and diastolic pressure to reduce cardiovascular risk.
  • Hypertensive emergencies: provides rapid blood pressure reduction to prevent end‑organ damage.
  • Hypertension associated with pheochromocytoma: controls catecholamine‑induced spikes in blood pressure.

How It Works

  • Labetalol exerts a mixed non‑selective β‑adrenergic and selective α1‑adrenergic blockade. By inhibiting β1 receptors, it reduces heart rate and myocardial contractility, while β2 blockade causes mild vasoconstriction. Concurrent α1 antagonism leads to vasodilation of peripheral vessels, together decreasing cardiac output and systemic vascular resistance, resulting in lowered arterial pressure.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Nausea
  • Flushing
  • Nasal congestion

Serious or Rare Side Effects

  • Severe hypotension
  • Bronchospasm, especially in asthmatic patients
  • Hepatic dysfunction or jaundice
  • Cardiac conduction abnormalities (e.g., heart block)
  • Acute heart failure exacerbation
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Asthma or chronic obstructive pulmonary disease: use with caution due to β2 blockade.
  • Hepatic impairment: dose adjustment may be required.
  • Abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Diabetes mellitus: monitor glucose as β‑blockade may mask hypoglycaemia symptoms.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Labetalol can interact with other medicines, influencing its efficacy and safety.

Major Interactions (Avoid)

  • Concomitant use with other antihypertensives (e.g., ACE inhibitors, diuretics) may cause profound hypotension.
  • Combined with other β‑blockers can lead to excessive β‑blockade and bradycardia.
  • Interaction with calcium channel blockers (especially verapamil or diltiazem) may increase risk of heart block.

Moderate Interactions (Monitor Closely)

  • Clonidine: may require dose adjustment to prevent severe blood pressure drops.
  • NSAIDs: can reduce antihypertensive effect of labetalol.
  • Antidiabetic agents: β‑blockade may mask hypoglycaemia signs, requiring glucose monitoring.
  • Antidepressants (e.g., tricyclics): may enhance cardiac conduction effects.
  • Anesthetic agents: may potentiate hypotensive response during surgery.

Frequently Asked Questions

Labetalol Tillomed Laboratories is prescribed for essential hypertension, hypertensive emergencies, and hypertension linked to pheochromocytoma. It helps lower blood pressure by acting on both beta and alpha‑1 receptors, providing a balanced reduction in cardiac output and vascular resistance.

Labetalol Hydrochloride blocks non‑selective β‑adrenergic receptors and selectively antagonizes α1‑adrenergic receptors. This dual action reduces heart rate, myocardial contractility, and causes peripheral vasodilation, together leading to a decrease in systemic blood pressure.

The dosage of Labetalol Tillomed Laboratories is individualized by the prescribing clinician based on the patient’s blood pressure, clinical condition, and response to therapy. No fixed regimen is provided here; the prescriber determines the appropriate dose and titration schedule.

Safety data for Labetalol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Labetalol’s unique combination of β‑blockade and α1‑blockade distinguishes it from pure β‑blockers or ACE inhibitors. This dual mechanism offers effective blood pressure control, especially in situations like hypertensive emergencies, where rapid reduction is needed, while potentially causing fewer reflex tachycardia events compared with pure vasodilators.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Labetalol Tillomed Laboratories is taken orally, usually with or without food as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include severe hypotension, bronchospasm in patients with asthma or COPD, hepatic dysfunction, and cardiac conduction abnormalities such as heart block. Patients should be monitored closely for these events, especially during dose initiation or escalation.

Labetalol is contraindicated in patients with known hypersensitivity to labetalol or any component of the formulation, severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and in those with uncompensated heart failure. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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