Product image of Labiriad (Aciclovir) supplied by GNH India

Labiriad

Active Ingredient:
Aciclovir
Origin:
EU

Labiriad (Aciclovir)

Aciclovir, the active ingredient in Labiriad, is an antiviral presented as a topical formulation for gingival use. It is employed to manage infections caused by the herpes simplex virus in the oral cavity and related tissues.

GNH India supplies Labiriad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vectans Pharma

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Indications & Clinical Uses

Labiriad, an antiviral agent, is used to treat conditions caused by herpes simplex virus replication.

  • Herpes labialis: reduces lesion duration and pain.
  • Herpes genitalis: alleviates symptoms and limits viral shedding.
  • Herpes simplex gingivostomatitis: controls oral lesions and promotes healing.

How It Works

  • Aciclovir is a nucleoside analogue that is phosphorylated by viral thymidine kinase and subsequently converted to aciclovir triphosphate. The triphosphate competitively inhibits viral DNA polymerase, terminating DNA chain elongation and preventing viral DNA synthesis, thereby limiting replication of herpes simplex virus.

Side Effects

Adverse reactions may occur with topical gingival use of Labiriad.

Common Side Effects

  • Local irritation: mild burning or stinging at the application site.
  • Redness: transient erythema of the gingiva.
  • Dryness: reduced salivary flow in the treated area.
  • Taste alteration: temporary metallic or bitter taste.
  • Mild swelling: localized edema.

Serious or Rare Side Effects

  • Allergic reaction: rash, urticaria, or angioedema.
  • Severe mucosal ulceration: extensive tissue breakdown.
  • Systemic absorption effects: rare nephrotoxicity.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane involvement.
  • Anaphylaxis: rapid onset of respiratory distress and hypotension.

Precautions & Warnings

When using Labiriad, consider the following safety measures.

  • Assess allergy history: avoid if known hypersensitivity to aciclovir or related compounds.
  • Monitor renal function: caution in patients with impaired kidney function.
  • Use as directed: apply only to affected gingival areas.
  • Avoid concurrent ocular exposure: prevent contact with eyes.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Labiriad may interact with other medicines; awareness of potential interactions is important.

Major Interactions (Avoid)

  • Probenecid: may increase systemic aciclovir levels.
  • Cimetidine: can reduce renal clearance of aciclovir.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase risk of renal impairment.
  • Nephrotoxic agents (e.g., aminoglycosides): monitor kidney function.
  • Immunosuppressants: watch for altered viral activity.
  • Other antiviral agents: assess for additive toxicity.

Frequently Asked Questions

Labiriad contains aciclovir and is used to treat herpes simplex virus infections affecting the oral cavity, such as gingivostomatitis, labial herpes, and related lesions. It helps reduce symptom severity and accelerates lesion healing when applied to the affected gingival area.

Aciclovir is a nucleoside analogue that, after activation by viral thymidine kinase, becomes aciclovir triphosphate. This metabolite inhibits viral DNA polymerase, halting DNA chain elongation and preventing replication of the herpes simplex virus at the site of application.

The specific dosing regimen for Labiriad is determined by the prescribing healthcare professional based on the infection type, severity, and patient factors. Patients should follow the prescriber’s instructions and not alter the dosage without medical advice.

Safety data for topical aciclovir during pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any risks before prescribing Labiriad to pregnant or nursing individuals.

To request Labiriad, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Labiriad’s active ingredient, aciclovir, is a first‑line antiviral for herpes simplex infections. Compared with newer agents such as valacyclovir, aciclovir has a well‑established safety profile but may require more frequent application. Choice of therapy depends on clinical judgment, patient preference and cost considerations.

Store Labiriad at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Ensure the container is tightly closed to maintain product stability and prevent contamination.

Labiriad is applied topically to the affected gingival area. The prescribed amount is spread gently over the lesion using a clean applicator or fingertip, following the healthcare provider’s instructions regarding frequency and duration of treatment.

Serious adverse reactions, although rare, include severe allergic responses such as rash, urticaria, angioedema, Stevens‑Johnson syndrome, and anaphylaxis. Systemic toxicity like nephrotoxicity may occur with excessive absorption, especially in patients with renal impairment.

Labiriad should be avoided in individuals with a known hypersensitivity to aciclovir or any component of the formulation. Patients with severe renal dysfunction should use it only under medical supervision, and pregnant or breastfeeding women should consult their clinician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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