Product image of Labiriad (Aciclovir) supplied by GNH India

Labiriad

Active Ingredient:
Aciclovir
Origin:
EU

Labiriad (Aciclovir)

Aciclovir, the active ingredient in Labiriad, is a nucleoside analogue antiviral presented as a topical formulation for gingival use. It treats herpes simplex virus infections, including herpes labialis and herpes gingivostomatitis, in patients with oral lesions and provides localized antiviral activity to reduce symptom duration and improve patient comfort. The medication is applied directly to the affected gingival area to achieve rapid viral suppression.

GNH India supplies Labiriad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU manufacturing standards and is distributed from European facilities.

Manufacturer / TM Owner

Vectans Pharma

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Indications & Clinical Uses

Aciclovir is used to manage infections caused by herpes simplex viruses affecting the oral cavity.

  • Herpes simplex virus infections: reduces viral replication and accelerates healing of oral lesions.
  • Herpes labialis: shortens the duration of cold sores on the lips and surrounding mucosa.
  • Herpes gingivostomatitis: alleviates pain and promotes recovery of inflamed gingival tissues.

How It Works

  • After topical application, aciclovir penetrates infected epithelial cells and is phosphorylated by viral thymidine kinase to aciclovir monophosphate, then further converted to aciclovir triphosphate by cellular kinases. The triphosphate competitively inhibits viral DNA polymerase and incorporates into viral DNA, causing premature chain termination and halting viral replication, thereby limiting infection spread.

Side Effects

Aciclovir may cause local and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Mild burning sensation at the application site
  • Transient erythema of the gingiva
  • Mild itching or tingling
  • Dryness of oral mucosa

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Significant ulceration of gingival tissue
  • Systemic hypersensitivity with rash
  • Renal impairment in susceptible patients

Precautions & Warnings

When using Labiriad, consider the following precautions to ensure safe and effective therapy.

  • Assess allergy: verify patient has no known hypersensitivity to aciclovir or related compounds.
  • Use limited duration: apply only for the prescribed treatment period to avoid resistance.
  • Monitor renal function: adjust use in patients with impaired kidney function.
  • Avoid use on extensive oral lesions: limit to localized areas to reduce systemic absorption.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Aciclovir can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Probenecid: may increase aciclovir plasma levels, raising risk of toxicity.
  • Immunosuppressants (e.g., cyclosporine): may enhance viral replication risk.

Moderate Interactions (Monitor Closely)

  • Nephrotoxic agents (e.g., aminoglycosides): monitor renal function.
  • Other antivirals (e.g., valacyclovir): avoid concurrent use without supervision.
  • Live vaccines: may reduce vaccine efficacy.

Frequently Asked Questions

Labiriad contains aciclovir and is indicated for the treatment of oral infections caused by herpes simplex virus, including herpes labialis (cold sores) and herpes gingivostomatitis. It helps reduce viral replication, shorten lesion duration, and relieve associated pain in the affected oral tissues.

Aciclovir is converted inside infected cells to aciclovir triphosphate, which mimics the natural building blocks of DNA. This active form binds to viral DNA polymerase, blocking the addition of nucleotides and causing premature termination of viral DNA synthesis, thereby inhibiting virus replication.

The specific dosage and frequency of Labiriad are determined by the prescribing healthcare professional based on the severity of the infection, patient age, and clinical response. Patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Safety data for aciclovir in pregnancy and lactation are limited. The decision to use Labiriad during pregnancy or while breastfeeding should be made by a qualified healthcare provider after weighing potential benefits against possible risks to the mother and infant.

To request Labiriad, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Labiriad’s topical aciclovir formulation offers localized delivery directly to oral lesions, which can provide faster symptom relief compared with systemic antivirals that require oral or intravenous administration. It is particularly useful for mild to moderate oral herpes infections where targeted therapy is preferred.

Store Labiriad at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme temperatures to maintain its stability and effectiveness.

Labiriad is applied directly to the affected gingival or oral area using the supplied applicator or a clean fingertip. The medication should be spread thinly over the lesion, following the prescriber’s instructions regarding frequency and duration of treatment.

Serious adverse reactions, though rare, can include severe allergic responses such as anaphylaxis, extensive ulceration of gingival tissue, systemic hypersensitivity with rash, and renal impairment in patients with pre‑existing kidney disease. Prompt medical attention is required if any of these occur.

Labiriad should be avoided in individuals with a known hypersensitivity to aciclovir or any component of the formulation. Patients with severe renal dysfunction should consult a healthcare professional before use, as dose adjustments may be necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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