Product image of Labrycor (Isoprenaline Hydrochloride) supplied by GNH India

Labrycor

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Labrycor (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride, the active ingredient in Labrycor, is a beta‑adrenergic agonist (non‑selective) presented as an injection solution for intravenous use. It treats bradycardia, heart block, and cardiac arrest in acute care settings.

GNH India supplies Labrycor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. Originating from the European Union market, the product meets EU quality standards. The supply chain adheres to stringent regulatory requirements ensuring product integrity.

Manufacturer / TM Owner

Macure Healthcare Limited

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Indications & Clinical Uses

Isoprenaline Hydrochloride is used in cardiovascular emergencies to increase heart rate and improve conduction.

  • Bradycardia: restores adequate heart rate in patients with symptomatic slow heart rhythm.
  • Heart block: improves atrioventricular conduction in second‑degree or higher block.
  • Cardiac arrest: provides temporary cardiac stimulation during resuscitation efforts.

How It Works

  • Isoprenaline Hydrochloride non‑selectively stimulates β1 and β2 adrenergic receptors on cardiac myocytes, raising intracellular cyclic AMP levels. This enhances pacemaker activity, increases myocardial contractility, and accelerates AV‑node conduction, resulting in a faster heart rate and stronger cardiac output.

Side Effects

Isoprenaline Hydrochloride may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Tachycardia: excessive increase in heart rate.
  • Hypertension: elevated blood pressure.
  • Headache: mild to moderate intensity.
  • Tremor: fine shaking of hands or limbs.
  • Nausea: gastrointestinal discomfort.
  • Palpitations: awareness of rapid heartbeat.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced blood flow to heart muscle.
  • Severe hypotension: dangerous drop in blood pressure.
  • Pulmonary edema: fluid accumulation in lungs.
  • Anaphylactic reaction: life‑threatening allergy.
  • Ventricular fibrillation: life‑threatening arrhythmia.

Precautions & Warnings

When using Isoprenaline Hydrochloride, careful monitoring and specific precautions are essential to ensure patient safety.

  • Cardiac monitoring: continuous ECG and blood pressure monitoring during infusion.
  • Dose titration: adjust infusion rate based on clinical response and hemodynamic parameters.
  • Contraindications: avoid in patients with pheochromocytoma or severe tachyarrhythmias.
  • Caution in ischemic heart disease: use only under strict supervision due to risk of myocardial ischemia.
  • Pregnancy and lactation: safety not established; weigh potential benefits against risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Isoprenaline Hydrochloride can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Beta‑blockers: antagonize therapeutic effect.
  • Calcium channel blockers: may exacerbate hypotension.
  • MAO inhibitors: increase risk of severe hypertension.
  • Tricyclic antidepressants: potentiate arrhythmic risk.

Moderate Interactions (Monitor Closely)

  • Diuretics: may amplify electrolyte disturbances.
  • Digoxin: heightened risk of arrhythmias.
  • ACE inhibitors: additive blood pressure lowering.
  • General anesthetics: possible synergistic cardiovascular depression.
  • Antihypertensives: may require dose adjustments.

Frequently Asked Questions

Labrycor contains Isoprenaline Hydrochloride, a non‑selective beta‑adrenergic agonist used in acute cardiovascular settings to treat bradycardia, heart block and cardiac arrest by increasing heart rate and contractility.

It stimulates both β1 and β2 adrenergic receptors, raising cyclic AMP in cardiac cells, which accelerates pacemaker activity, boosts myocardial contractile force, and speeds AV‑node conduction, resulting in a faster and stronger heartbeat.

The dosing regimen is determined by the prescribing clinician based on the patient’s condition, response, and monitoring parameters; Labrycor is administered intravenously as an infusion under controlled medical supervision.

Safety data for Isoprenaline Hydrochloride in pregnancy and lactation are limited; it should only be used when the potential maternal benefit justifies any possible risk to the fetus or infant, and under specialist guidance.

Submit an enquiry on the Labrycor product page at gnhindia.com, providing the required quantity and institutional credentials; GNH India will verify eligibility, then respond with pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Compared with agents such as dopamine or epinephrine, Isoprenaline provides a more pronounced β‑adrenergic effect with less α‑mediated vasoconstriction, making it especially useful for pure chronotropic support, though the choice depends on the clinical context.

Labrycor should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken; keep the vial in its original packaging until use.

Labrycor is supplied as an injectable solution for intravenous infusion; it is typically diluted in a compatible carrier fluid and administered via a controlled infusion pump with continuous hemodynamic monitoring.

Serious adverse events include severe hypotension, myocardial ischemia, ventricular arrhythmias, and allergic reactions; immediate medical intervention is required if these occur.

Patients with known pheochromocytoma, uncontrolled severe tachyarrhythmias, or hypersensitivity to Isoprenaline should not be given Labrycor, and it should be used with caution in individuals with ischemic heart disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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