Product image of Lacerol Hta Retard (Diltiazem Hydrochloride) supplied by GNH India

Lacerol Hta Retard

Active Ingredient:
Diltiazem Hydrochloride
Origin:
EU

Lacerol Hta Retard (Diltiazem Hydrochloride)

Diltiazem Hydrochloride, the active ingredient in Lacerol Hta Retard, is a calcium channel blocker presented as a modified‑release oral tablet for oral use. It treats hypertension and angina in adult patients.
GNH India supplies Lacerol Hta Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lacer S.A.

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Indications & Clinical Uses

Lacerol Hta Retard, a calcium channel blocker, is employed in several cardiovascular conditions.

  • Hypertension: lowers elevated blood pressure by relaxing vascular smooth muscle.
  • Chronic stable angina: reduces frequency of chest pain episodes by improving myocardial oxygen supply.
  • Angina pectoris: alleviates acute chest discomfort through coronary vasodilation.
  • Certain cardiac arrhythmias: helps control heart rate by decreasing atrioventricular nodal conduction.

How It Works

  • Diltiazem Hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth muscle cells, reducing calcium influx. This inhibition leads to vasodilation of peripheral arteries, decreased myocardial contractility, and slowed conduction through the atrioventricular node, collectively lowering blood pressure and myocardial oxygen demand.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain often occurring early in therapy.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the lower extremities due to fluid retention.
  • Dizziness: sensation of light‑headedness, especially when standing.
  • Nausea: mild gastrointestinal upset.
  • Constipation: reduced bowel motility.

Serious or Rare Side Effects

  • Severe hypotension: markedly low blood pressure requiring medical attention.
  • Bradycardia: abnormally slow heart rate that may cause fatigue.
  • Heart block: impaired electrical conduction in the heart.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Myocardial infarction: rare occurrence of heart attack.

Precautions & Warnings

Lacerol Hta Retard requires careful monitoring in several clinical situations.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Heart rate assessment: watch for bradycardia, especially with concomitant beta‑blockers.
  • Hepatic impairment: use caution and consider dose adjustment in patients with liver disease.
  • Abrupt discontinuation: avoid sudden stop to prevent rebound hypertension.
  • Renal impairment: adjust dose in severe kidney dysfunction.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Diltiazem Hydrochloride can interact with various medicines, influencing its safety and efficacy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase diltiazem levels.
  • Beta‑blockers: combined use can cause marked bradycardia.
  • Digoxin: concurrent use may raise digoxin concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce diltiazem effectiveness.
  • NSAIDs: can diminish antihypertensive response.
  • Alcohol: may enhance dizziness and hypotension.
  • Diuretics: may potentiate blood‑pressure lowering effects.

Frequently Asked Questions

Lacerol Hta Retard contains diltiazem hydrochloride, a calcium channel blocker indicated for the management of hypertension, chronic stable angina, angina pectoris, and certain cardiac arrhythmias. It works by relaxing blood vessels and reducing the heart's workload, helping to control blood pressure and relieve chest pain associated with reduced coronary blood flow.

Diltiazem hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth muscle cells. This action reduces calcium entry, leading to vasodilation of peripheral arteries, decreased myocardial contractility, and slowed atrioventricular nodal conduction. The combined effect lowers systemic blood pressure and reduces the oxygen demand of the heart, which alleviates angina.

The specific dose of Lacerol Hta Retard is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Diltiazem hydrochloride is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no adequate human studies. It should be used during pregnancy only if clearly needed. Limited data are available for breastfeeding; the decision to continue should be made by the prescriber after weighing benefits and potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the enquiry, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lacerol Hta Retard, as a calcium channel blocker, offers a distinct mechanism compared with ACE inhibitors, ARBs, or beta‑blockers. It is particularly useful in patients who need both blood‑pressure control and anti‑anginal effects. Compared with non‑dihydropyridine calcium blockers, diltiazem provides moderate vasodilation with less peripheral edema, making it a balanced choice for many cardiovascular profiles.

Lacerol Hta Retard should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the tablets away from excessive heat and humidity to maintain stability and potency throughout the shelf life.

Lacerol Hta Retard is taken orally, usually as a modified‑release tablet. It should be swallowed whole with a glass of water and not chewed or crushed, to ensure the intended release profile and therapeutic effect.

The most serious risks include severe hypotension, marked bradycardia, heart block, and rare cases of hepatic dysfunction or severe allergic reactions. Patients should be monitored for signs of these events, especially when initiating therapy or adjusting the dose, and seek immediate medical attention if they occur.

Lacerol Hta Retard is contraindicated in patients with known hypersensitivity to diltiazem or other calcium channel blockers, those with severe hypotension, advanced heart block without a pacemaker, and certain forms of sick sinus syndrome. Caution is also advised for individuals with severe hepatic impairment or those taking interacting medications that could elevate diltiazem levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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