Product image of Lacerol Retard (Diltiazem) supplied by GNH India

Lacerol Retard

Active Ingredient:
Diltiazem
Origin:
EU

Lacerol Retard (Diltiazem)

Diltiazem, the active ingredient in Lacerol Retard, is a calcium channel blocker (non‑dihydropyridine) presented as an oral tablet for oral use. It is employed to manage hypertension, angina pectoris and to control ventricular rate in atrial fibrillation in adult patients.

GNH India supplies Lacerol Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lacer S.A.

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Indications & Clinical Uses

  • Diltiazem is used in cardiovascular conditions that involve elevated blood pressure, myocardial oxygen demand, or abnormal heart rhythm.
  • Hypertension: lowers systemic blood pressure by reducing peripheral vascular resistance.
  • Angina pectoris: improves myocardial oxygen supply by decreasing cardiac workload and dilating coronary vessels.
  • Rate control in atrial fibrillation: slows ventricular response through negative chronotropic effects on the atrioventricular node.

How It Works

  • Diltiazem blocks L‑type calcium channels in cardiac myocytes and vascular smooth muscle, leading to reduced intracellular calcium influx. This decreases myocardial contractility and slows conduction through the atrioventricular node, while causing vasodilation of peripheral arteries, which together lower blood pressure and relieve anginal symptoms.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Dizziness or light‑headedness: related to blood pressure reduction.
  • Flushing: warm sensation, usually resolves with continued use.
  • Peripheral edema: swelling of ankles or lower legs.
  • Constipation: reduced gastrointestinal motility.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Bradycardia: markedly slow heart rate, may require medical attention.
  • Severe hypotension: sudden drop in blood pressure causing faintness.
  • AV block: impaired atrioventricular conduction, potentially life‑threatening.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Heart failure exacerbation: worsening symptoms in susceptible patients.

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Monitor blood pressure: check regularly during dose titration.
  • Assess heart rate: watch for bradycardia, especially in patients with conduction disorders.
  • Avoid in severe hepatic impairment: dose adjustment may be required.
  • Caution with concomitant beta‑blockers: risk of excessive heart rate reduction.
  • Pregnancy and lactation: use only if benefits outweigh risks; safety not established.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Diltiazem may interact with several medicines; review patient medication lists.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase diltiazem plasma levels.
  • Co‑administration with other non‑dihydropyridine calcium channel blockers: additive negative inotropic and chronotropic effects.
  • Combination with beta‑blockers: heightened risk of severe bradycardia and AV block.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce diltiazem efficacy.
  • Digoxin: increased serum digoxin concentrations, requiring level monitoring.
  • Simvastatin: elevated risk of myopathy due to CYP3A4 competition.

Frequently Asked Questions

Lacerol Retard contains diltiazem, which is prescribed to treat high blood pressure, relieve chest pain from angina, and control the ventricular rate in patients with atrial fibrillation. These indications reflect its role as a calcium channel blocker that relaxes blood vessels and moderates heart rhythm.

Diltiazem blocks L‑type calcium channels in cardiac muscle and vascular smooth muscle. By reducing calcium entry, it lessens heart muscle contraction strength, slows electrical conduction through the atrioventricular node, and dilates peripheral arteries, collectively lowering blood pressure and decreasing myocardial oxygen demand.

The appropriate dose of Lacerol Retard is determined by a qualified prescriber based on the individual’s medical condition, response to therapy, and other medications. Patients should follow the dosing instructions provided by their healthcare professional and not adjust the dose on their own.

Safety of diltiazem in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacerol Retard (diltiazem) belongs to the non‑dihydropyridine calcium channel blocker class, offering both blood‑pressure reduction and rate‑control benefits. Compared with beta‑blockers, it has less impact on bronchial tone, making it a useful alternative for patients with respiratory concerns, while providing similar anti‑ischemic effects.

Lacerol Retard should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Lacerol Retard is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, as the extended‑release formulation is designed to release diltiazem gradually over time.

The most serious adverse events include severe bradycardia, marked hypotension, atrioventricular block, and rare cases of hepatic dysfunction or allergic reactions. Patients experiencing faintness, very slow heart rate, or signs of liver injury should seek immediate medical attention.

Lacerol Retard is contraindicated in patients with known hypersensitivity to diltiazem or other calcium channel blockers, those with severe sinus node dysfunction without a pacemaker, and individuals with second‑ or third‑degree AV block unless a pacemaker is present.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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