Lacerol Retard (Diltiazem Hydrochloride)

Diltiazem blocks L‑type calcium channels in vascular smooth muscle and cardiac cells, reducing calcium entry during depolarization. This causes arterial vasodilation, lowers peripheral resistance, and decreases myocardial contractility and heart rate. The resulting effect lowers blood pressure, eases the heart’s oxygen demand, and slows conduction through the AV node, aiding rhythm control.

The appropriate dose of Lacerol Retard is set by the prescribing clinician based on the individual’s medical condition, response to therapy, and factors such as age, liver function, and concomitant medications. Dosage adjustments may be required for patients with hepatic impairment or when used with interacting drugs.

Safety of diltiazem during pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and risks with their healthcare provider.

To order Lacerol Retard, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team will then provide pricing, availability, shipping details and any necessary import documentation.

Lacerol Retard (diltiazem) is a non‑dihydropyridine calcium channel blocker, offering both vasodilatory and negative‑inotropic effects. Compared with dihydropyridine agents such as amlodipine, diltiazem provides more pronounced heart‑rate reduction and AV‑node slowing, making it useful for certain arrhythmias, while amlodipine is often preferred for pure antihypertensive therapy with less effect on heart rate.

Lacerol Retard should be stored below 25 °C in a dry place, protected from moisture and direct sunlight. Keep the tablets in the original container with the lid tightly closed. Do not refrigerate or freeze the product, and ensure it is out of reach of children.

Lacerol Retard is taken orally as a tablet. Swallow the tablet whole with a glass of water; it may be taken with or without food according to the prescriber’s advice. Do not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

The most serious adverse events include severe bradycardia, atrioventricular block, and marked hypotension, which can lead to syncope or cardiovascular collapse. Rarely, hepatic dysfunction or life‑threatening allergic reactions may occur. Patients should be monitored for these signs, especially when initiating therapy or adjusting doses.

Lacerol Retard is contraindicated in patients with second‑ or third‑degree AV block, sick‑sinus syndrome without a functioning pacemaker, severe heart failure (NYHA class IV), and in those with known hypersensitivity to diltiazem or any component of the formulation. Caution is also advised for individuals with significant hepatic impairment.