Product image of Lacerol Retard (Diltiazem Hydrochloride) supplied by GNH India

Lacerol Retard

Active Ingredient:
Diltiazem Hydrochloride
Origin:
EU

Lacerol Retard (Diltiazem Hydrochloride)

Diltiazem Hydrochloride, the active ingredient in Lacerol Retard, is a calcium channel blocker presented as an extended‑release tablet for oral use. It is indicated for the treatment of hypertension, chronic stable angina, and rate control in atrial fibrillation in adult patients.
GNH India supplies Lacerol Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lacer S.A.

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Indications & Clinical Uses

  • Diltiazem, a calcium channel blocker, is used in cardiovascular conditions that involve elevated blood pressure or myocardial oxygen demand.
  • Hypertension: lowers systemic blood pressure by vasodilation and reduced cardiac contractility.
  • Chronic stable angina: decreases frequency of angina attacks by improving coronary blood flow and reducing myocardial oxygen demand.
  • Atrial fibrillation (rate control): slows ventricular rate by decreasing AV‑node conduction.

How It Works

  • Diltiazem blocks L‑type calcium channels in cardiac and vascular smooth muscle, limiting calcium entry into cells. This reduces myocardial contractility and slows atrioventricular nodal conduction, while causing peripheral vasodilation, which together lower blood pressure and relieve angina symptoms.

Side Effects

Adverse reactions may occur with any medication. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Headache
  • Dizziness or light‑headedness
  • Flushing
  • Peripheral edema
  • Constipation
  • Nausea

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Hepatic dysfunction
  • Life‑threatening allergic reactions (e.g., Stevens‑Johnson syndrome)
  • Atrioventricular conduction disturbances

Precautions & Warnings

  • Before initiating therapy, several safety considerations are recommended.
  • Monitor blood pressure regularly: ensure therapeutic effect and avoid hypotension.
  • Assess cardiac function: especially in patients with existing conduction abnormalities.
  • Use caution in hepatic impairment: dose adjustments may be required.
  • Avoid abrupt discontinuation: tapering reduces risk of rebound hypertension.
  • Review concomitant medications affecting heart rate: adjust therapy as needed.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Diltiazem may interact with several drugs, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Beta‑blockers: increased risk of bradycardia and AV‑block.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): elevated diltiazem plasma levels.
  • Digoxin: heightened digoxin concentrations and toxicity.

Moderate Interactions (Monitor Closely)

  • Verapamil or other calcium‑channel blockers: additive cardiac depressant effects.
  • ACE inhibitors or ARBs: potential for excessive hypotension.
  • CYP3A4 inducers (e.g., rifampin): reduced diltiazem efficacy.

Frequently Asked Questions

Lacerol Retard contains diltiazem hydrochloride, a calcium channel blocker indicated for the management of hypertension, chronic stable angina, and rate control in atrial fibrillation. It is prescribed by healthcare professionals to lower blood pressure, relieve chest pain, and help regulate heart rhythm.

Diltiazem blocks L‑type calcium channels in cardiac and vascular smooth muscle, reducing calcium influx. This decreases myocardial contractility and slows conduction through the atrioventricular node, while causing peripheral vasodilation, together lowering blood pressure and alleviating angina.

The dosage of Lacerol Retard is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. The prescriber determines the appropriate strength and frequency, which may be adjusted during therapy to achieve optimal blood pressure control or angina relief.

Safety of diltiazem during pregnancy and lactation has not been definitively established; it is classified as Category C in many regions. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and decisions are made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacerol Retard (diltiazem) is a non‑dihydropyridine calcium channel blocker, offering both vasodilatory and negative‑chronotropic effects, unlike dihydropyridine agents such as amlodipine which primarily cause vasodilation. This dual action makes diltiazem useful for hypertension, angina, and atrial fibrillation rate control, whereas other classes may be preferred for isolated blood pressure reduction.

Lacerol Retard tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect them from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout the shelf life.

Lacerol Retard is taken orally, usually once daily with or without food, as directed by the prescribing healthcare professional. The extended‑release formulation provides a gradual release of diltiazem over several hours, supporting consistent blood pressure control and angina relief.

Serious adverse events, though uncommon, can include severe bradycardia, hypotension, heart block, hepatic dysfunction, and life‑threatening allergic reactions such as Stevens‑Johnson syndrome. Patients should be monitored for these signs, and immediate medical attention is required if they occur.

Lacerol Retard is contraindicated in patients with known hypersensitivity to diltiazem or other calcium channel blockers, those with severe hypotension, sick sinus syndrome, second‑ or third‑degree atrioventricular block without a pacemaker, and in individuals with acute myocardial infarction where its use may be harmful. Consultation with a physician is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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