Product image of Lacidipin Teva (Lacidipine) supplied by GNH India

Lacidipin Teva

Active Ingredient:
Lacidipine
Origin:
EU

Lacidipin Teva (Lacidipine)

Lacidipine, the active ingredient in Lacidipin, is a calcium channel blocker presented as an oral tablet for systemic use. It lowers elevated blood pressure by relaxing vascular smooth muscle and is prescribed for adults with hypertension and is commonly used in clinical practice to achieve target blood pressure levels. The drug is absorbed after ingestion and reaches peak plasma concentrations within a few hours.

GNH India supplies Lacidipin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

  • Lacidipine is indicated for the management of hypertension, a condition characterized by chronically elevated arterial pressure.
  • Hypertension: reduces systolic and diastolic blood pressure in patients with essential hypertension.
  • Isolated systolic hypertension: helps lower high systolic readings in elderly patients.
  • Secondary hypertension: assists in controlling blood pressure when caused by underlying disorders.

How It Works

  • Lacidipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells, preventing calcium influx that is necessary for muscle contraction. This inhibition leads to relaxation of arterial smooth muscle, resulting in vasodilation and a decrease in peripheral vascular resistance. The reduced resistance lowers systemic blood pressure without significant negative inotropic effects on the heart.

Side Effects

Lacidipine may be associated with several adverse reactions, ranging from mild to severe.

Common Side Effects

  • Headache: mild to moderate headache reported.
  • Flushing: transient facial flushing.
  • Dizziness: sensation of light‑headedness.
  • Peripheral edema: swelling of ankles or lower limbs.
  • Nausea: occasional upset stomach.
  • Tachycardia: increased heart rate.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic dysfunction: elevated liver enzymes.
  • Angioedema: swelling of face, lips, or airway.
  • Severe allergic reaction: rash, itching, or anaphylaxis.
  • Cardiac arrhythmia: irregular heart rhythm.

Precautions & Warnings

When prescribing lacidipine, clinicians should observe several safety considerations.

  • Monitor blood pressure: adjust dose based on therapeutic response.
  • Assess hepatic function: use caution in patients with liver impairment.
  • Caution in elderly: increased sensitivity to hypotensive effects.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Use with caution in heart failure: may exacerbate symptoms.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lacidipine can interact with other medicines, influencing its plasma levels or blood‑pressure effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise lacidipine concentrations.
  • Grapefruit juice: can increase drug exposure and risk of hypotension.
  • Co‑administration with other calcium‑channel blockers (e.g., verapamil): additive vasodilatory effect.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce lacidipine efficacy.
  • Diuretics (e.g., thiazides): may enhance blood‑pressure lowering, requiring dose adjustment.

Frequently Asked Questions

Lacidipin contains lacidipine, a calcium channel blocker prescribed to treat hypertension, helping lower high blood pressure and reduce the risk of cardiovascular complications. It is used in adult patients with essential hypertension and may be part of combination therapy.

Lacidipine blocks L‑type calcium channels in vascular smooth muscle, preventing calcium entry that triggers contraction. This causes relaxation of arterial walls, vasodilation, and a reduction in peripheral resistance, which lowers systemic blood pressure.

The dosage of lacidipine is individualized by the prescribing clinician based on the patient’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. The prescriber determines the appropriate strength and dosing schedule.

The safety of lacidipine during pregnancy and lactation has not been established. It is generally classified as contraindicated or used only if the potential benefit justifies the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Lacidipin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with other calcium‑channel blockers, lacidipine has a long‑acting profile and high lipophilicity, providing sustained blood‑pressure control. Unlike ACE inhibitors or beta‑blockers, it primarily acts on vascular smooth muscle without significant effects on heart rate, making it suitable for patients who need vasodilation without negative inotropic impact.

Lacidipin tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Do not store in humid areas such as bathrooms, and keep out of reach of children.

Lacidipin is taken orally, usually with a glass of water. It may be taken with or without food, but consistent administration with respect to meals helps maintain stable drug levels. Patients should follow the prescriber’s instructions regarding timing and any dietary considerations.

The most serious adverse events include severe hypotension, myocardial infarction, hepatic dysfunction, angioedema, and life‑threatening allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like fainting, chest pain, severe swelling, or rash.

Lacidipine is contraindicated in patients with known hypersensitivity to the drug or other calcium‑channel blockers, in those with severe aortic stenosis, and in individuals with uncontrolled heart failure. Caution is also advised for patients with significant liver impairment or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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