Product image of Lacidipine Double-E Pharma (Lacidipine) supplied by GNH India

Lacidipine Double-E Pharma

Active Ingredient:
Lacidipine
Origin:
EU

Lacidipine Double-E Pharma (Lacidipine)

Lacidipine, the active ingredient in Lacidipine Double-E Pharma, is a calcium channel blocker (dihydropyridine) presented as a tablet for oral use. It treats hypertension in adult patients.\n\nGNH India supplies Lacidipine Double-E Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Double-E Pharma Ltd

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Pack/s
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Indications & Clinical Uses

  • Lacidipine is a dihydropyridine calcium‑channel blocker used to manage high blood pressure by relaxing vascular smooth muscle.\n\n- Hypertension: lowers systolic and diastolic pressure, reducing cardiovascular risk.\n- Essential hypertension: provides sustained blood‑pressure control in primary hypertension.\n- Isolated systolic hypertension: improves pulse pressure in elderly patients with elevated systolic values.

How It Works

  • Lacidipine selectively inhibits L‑type calcium channels in vascular smooth‑muscle cells, decreasing calcium influx. This results in arterial vasodilation, reduced peripheral vascular resistance, and consequently a fall in systemic blood pressure without significant negative inotropic effects on the heart.

Side Effects

  • Lacidipine may cause a range of adverse reactions, most of which are mild and reversible.\n\nCommon Side Effects:\n- Headache: mild to moderate intensity, often transient.\n- Flushing: warmth and redness, typically occurring shortly after dosing.\n- Peripheral edema: swelling of ankles or lower legs due to fluid accumulation.\n- Dizziness: sensation of light‑headedness, especially when standing quickly.\n\nSerious or Rare Side Effects:\n- Severe hypotension: marked drop in blood pressure that may cause fainting.\n- Hepatic dysfunction: abnormal liver enzymes or hepatitis.\n- Allergic reactions: rash, urticaria, or angioedema requiring immediate medical attention.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.\n\n- Blood pressure monitoring: obtain baseline readings and reassess regularly after dose changes.\n- Renal impairment: use cautiously in patients with severe renal dysfunction; monitor renal function.\n- Hepatic impairment: consider dose adjustment in moderate to severe liver disease.\n- Concomitant antihypertensives: avoid excessive hypotension when combined with other blood‑pressure‑lowering agents.\n- Pregnancy and lactation: safety not established; avoid unless clearly indicated.\n- Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

  • Lacidipine can interact with several drug classes, altering its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Potent CYP3A4 inhibitors: may raise lacidipine levels, increasing hypotension risk.\n- Co‑administration with other calcium‑channel blockers: additive vasodilation can cause severe hypotension.\n- Grapefruit juice: markedly enhances drug exposure, should be avoided.\n\nModerate Interactions (Monitor Closely):\n- Diuretics: may amplify antihypertensive effect; monitor blood pressure.\n- Beta‑blockers: combined effect on heart rate; watch for bradycardia.\n- NSAIDs: can diminish antihypertensive response and affect renal function; assess periodically.

Frequently Asked Questions

Lacidipine Double-E Pharma is a prescription tablet that contains the active ingredient lacidipine. It is used primarily to treat hypertension by lowering elevated blood‑pressure levels and helping to prevent complications associated with high blood pressure.

Lacidipine belongs to the dihydropyridine class of calcium‑channel blockers. It blocks L‑type calcium channels in arterial smooth muscle, which reduces calcium entry, causes vasodilation, and lowers peripheral vascular resistance, resulting in a decrease in systemic blood pressure.

The appropriate dose of Lacidipine Double-E Pharma is determined by the prescribing healthcare professional based on the individual’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. Patients should follow the prescriber’s instructions exactly.

Safety of lacidipine in pregnancy and lactation has not been established. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacidipine is a dihydropyridine calcium‑channel blocker, similar to amlodipine but with a longer half‑life and a slightly different side‑effect profile. Compared with ACE inhibitors or beta‑blockers, it primarily causes vasodilation without affecting heart rate, making it useful when a strong peripheral vasodilator is needed.

Lacidipine tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and keep out of reach of children.

The medication is taken orally, usually once daily, with a full glass of water. It can be taken with or without food, but patients should follow the prescribing physician’s guidance regarding timing relative to meals.

Serious adverse events include severe hypotension, which can cause fainting or shock, hepatic dysfunction manifested by abnormal liver enzymes, and allergic reactions such as rash, urticaria or angioedema that require immediate medical attention.

Patients with known hypersensitivity to lacidipine or any component of the tablet, those with severe hypotension, or individuals with uncontrolled heart failure should avoid this medication. A healthcare professional should evaluate any other contraindications before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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