Product image of Lacidipine Zentiva (Lacidipine) supplied by GNH India

Lacidipine Zentiva

Active Ingredient:
Lacidipine
Origin:
EU

Lacidipine Zentiva (Lacidipine)

Lacidipine, the active ingredient in Lacidipine Zentiva, is a calcium channel blocker presented as an oral tablet for oral use. It is used to treat hypertension in adult patients by lowering elevated blood pressure.

GNH India supplies Lacidipine Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

Lacidipine is a dihydropyridine calcium channel blocker indicated for the management of high blood pressure.

  • Hypertension: reduces systolic and diastolic blood pressure, helping to achieve target levels and lower cardiovascular risk.

How It Works

  • Lacidipine selectively blocks L‑type calcium channels on vascular smooth muscle, inhibiting calcium influx. This causes dose‑dependent vasodilation of arterial beds, decreases peripheral vascular resistance, and ultimately lowers systemic blood pressure without significant negative inotropic effects.

Side Effects

Lacidipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of ankles or lower legs.
  • Dizziness or light‑headedness.
  • Tachycardia: increased heart rate.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Angio‑edema: swelling of face, lips, or throat.
  • Arrhythmias: abnormal heart rhythms.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Blood pressure monitoring: check baseline and follow‑up readings to avoid excessive hypotension.
  • Hepatic function: use caution in patients with liver impairment and adjust therapy if needed.
  • Elderly patients: start at the lowest effective dose and monitor for dizziness.
  • Concomitant antihypertensives: assess risk of additive blood‑pressure lowering effects.
  • Discontinuation: avoid abrupt withdrawal; taper if long‑term therapy is stopped.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lacidipine can interact with several drug classes, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may markedly increase lacidipine plasma levels.
  • Other potent antihypertensives (e.g., ACE inhibitors, ARBs): risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce lacidipine effectiveness.
  • Non‑dihydropyridine calcium channel blockers (e.g., verapamil, diltiazem): additive cardiovascular effects.
  • Grapefruit juice: can increase drug exposure.
  • NSAIDs: may blunt antihypertensive response.
  • Diuretics: may enhance orthostatic hypotension.

Frequently Asked Questions

Lacidipine Zentiva is prescribed to lower elevated blood pressure in adults with hypertension. By relaxing arterial smooth muscle, it helps achieve target blood‑pressure levels and reduces the risk of cardiovascular complications associated with sustained hypertension.

Lacidipine selectively blocks L‑type calcium channels on vascular smooth‑muscle cells. This inhibition reduces calcium entry, causing arterial vasodilation, decreasing peripheral vascular resistance, and ultimately lowering systolic and diastolic blood pressure without significant negative effects on heart contractility.

The appropriate dose of Lacidipine Zentiva is determined by the prescribing clinician based on the patient’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Safety data for lacidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacidipine belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or ARBs, it has a more pronounced effect on peripheral resistance and may cause flushing or edema, while offering similar blood‑pressure‑lowering efficacy.

Lacidipine Zentiva tablets should be stored at room temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat, and direct sunlight to maintain product stability throughout its shelf life.

Lacidipine Zentiva is taken orally, usually once daily with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split unless specifically instructed.

Serious risks include severe hypotension, myocardial infarction, hepatic injury, and rare allergic reactions such as anaphylaxis or angio‑edema. Patients should seek immediate medical attention if they experience sudden dizziness, chest pain, jaundice, or swelling of the face and throat.

Lacidipine Zentiva is contraindicated in patients with known hypersensitivity to lacidipine or any component of the formulation, and in individuals with severe aortic stenosis or unstable angina. Caution is also advised for patients with significant liver disease or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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