Product image of Lacipil (Lacidipine) supplied by GNH India

Lacipil

Active Ingredient:
Lacidipine
Origin:
EU

Lacipil (Lacidipine)

Lacidipine, the active ingredient in Lacipil, is a calcium channel blocker presented as a tablet for oral use. It treats hypertension in adults by lowering blood pressure and reducing vascular resistance.
GNH India supplies Lacipil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Single Member A.E.B.E.

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Indications & Clinical Uses

  • Lacidipil is a dihydropyridine calcium channel blocker used to manage high blood pressure conditions.
  • Hypertension: reduces systemic vascular resistance to lower blood pressure.
  • Essential hypertension: provides sustained blood pressure control in primary hypertension.
  • Isolated systolic hypertension: helps lower elevated systolic pressure in older patients.

How It Works

  • Lacidipine selectively inhibits L-type calcium channels in vascular smooth muscle, preventing calcium influx. This leads to relaxation of arterial smooth muscle, vasodilation, and a consequent reduction in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Adverse reactions may occur with lacidipine therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness: especially upon standing.
  • Tachycardia: increased heart rate.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Angioedema: swelling of face, lips, or airway.
  • Hepatic dysfunction: elevated liver enzymes.
  • Myocardial infarction: rare cardiac event.
  • Arrhythmia: abnormal heart rhythms.
  • Allergic reaction: rash, itching, or anaphylaxis.

Precautions & Warnings

Patients should be counseled on safety considerations before starting lacidipine.

  • Blood pressure monitoring: check values before initiation and regularly thereafter.
  • Renal impairment: use with caution and monitor renal function.
  • Hepatic disease: consider dose adjustment or avoid if severe.
  • Concomitant antihypertensives: risk of additive hypotension.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lacidipine may interact with several drug classes.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole): increase plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampicin): reduce therapeutic effect.
  • Grapefruit juice: may elevate drug levels.

Moderate Interactions (Monitor Closely):\n- Other antihypertensives: additive blood pressure lowering.

  • Diuretics: potential electrolyte disturbances.
  • Beta‑blockers: may mask tachycardia response.

Frequently Asked Questions

Lacipil contains lacidipine, a calcium channel blocker indicated for the treatment of hypertension. It helps lower elevated blood pressure by relaxing arterial smooth muscle, thereby reducing peripheral vascular resistance and improving cardiovascular risk management.

Lacidipine selectively blocks L‑type calcium channels on vascular smooth‑muscle cells. By preventing calcium entry, it causes arterial vasodilation, which decreases peripheral resistance and leads to a reduction in systemic blood pressure.

The exact dosage of Lacipil is determined by the prescribing clinician based on the patient’s blood pressure, age, renal and hepatic function, and concomitant medications. Physicians typically start with a low dose and titrate as needed to achieve target blood pressure.

Safety data for lacidipine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the Lacipil product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacipil (lacidipine) belongs to the dihydropyridine calcium‑channel blocker class, offering potent arterial vasodilation. Compared with agents such as amlodipine, lacidipine has a longer half‑life and may cause less reflex tachycardia, but individual response and side‑effect profiles vary, so therapy should be individualized.

Lacipil tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, direct sunlight, and excessive heat to maintain potency throughout the shelf life.

Lacipil is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and avoid crushing or chewing the tablet.

Serious adverse events, though rare, include severe hypotension, angioedema, hepatic dysfunction, myocardial infarction, and life‑threatening allergic reactions. Patients should seek immediate medical attention if they experience symptoms such as sudden dizziness, swelling of the face or throat, chest pain, or jaundice.

Lacipil is contraindicated in patients with known hypersensitivity to lacidipine or any excipients, those with severe aortic stenosis, and individuals with uncontrolled heart failure. Caution is also advised for patients with significant liver or kidney impairment, and it should be avoided during pregnancy unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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