Product image of Lacipil (Lacidipine) supplied by GNH India

Lacipil

Active Ingredient:
Lacidipine
Origin:
EU

Lacipil (Lacidipine)

Lacidipine, the active ingredient in Lacipil, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension in adults. GNH India supplies Lacipil as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline S.P.A.

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Indications & Clinical Uses

  • Lacidipine is used to manage high blood pressure by acting on the vascular smooth muscle system.
  • Hypertension: lowers systolic and diastolic blood pressure, reducing the risk of cardiovascular events.

How It Works

  • Lacidipine selectively blocks L-type calcium channels in vascular smooth muscle cells, inhibiting calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation and a reduction in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Lacidipine may cause several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or feet.
  • Dizziness: sensation of light‑headedness, especially on standing.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Angioedema: swelling of the face, lips, tongue, or throat.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Cardiac arrhythmia: irregular heart rhythm that may be life‑threatening.

Precautions & Warnings

  • Before prescribing Lacipil, clinicians should consider several safety aspects.
  • Monitor blood pressure regularly: ensure therapeutic effect and avoid excessive hypotension.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Use caution in elderly patients: increased sensitivity to blood‑pressure lowering effects.
  • Avoid concomitant use with strong CYP3A4 inhibitors: may increase Lacidipine plasma levels.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Lacidipine can interact with other medicines, influencing its efficacy and safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise Lacidipine concentrations.
  • Grapefruit juice: can increase drug exposure and risk of hypotension.
  • Other antihypertensives causing additive blood‑pressure reduction.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce Lacidipine effectiveness.
  • Diuretics: may enhance orthostatic hypotension.
  • Beta‑blockers: may require dose adjustments to avoid excessive heart‑rate slowing.

Frequently Asked Questions

Lacipil contains the active ingredient lacidipine, which is prescribed to lower high blood pressure (hypertension). By reducing arterial resistance, it helps prevent complications such as stroke and heart attack in adult patients.

Lacidipine blocks L-type calcium channels in the smooth muscle of blood vessels. This inhibition prevents calcium‑mediated contraction, leading to vasodilation and a decrease in peripheral vascular resistance, which lowers systemic blood pressure.

The appropriate dose of Lacipil is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any concomitant medications. Dosage adjustments are made individually.

Safety data for lacidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Lacipil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacipil belongs to the calcium channel blocker class, which primarily causes vasodilation. Compared with ACE inhibitors or beta‑blockers, it may have a different side‑effect profile, such as a lower incidence of cough but a higher chance of peripheral edema. Choice of therapy depends on patient‑specific factors and physician judgment.

Lacipil tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Lacipil is taken orally, usually once daily with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include severe hypotension, which can cause fainting or shock, and rare events such as angioedema, hepatic dysfunction, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden weakness, or irregular heartbeats.

Lacipil is contraindicated in patients with known hypersensitivity to lacidipine or any component of the formulation, and it should be used with caution in individuals with severe liver disease, unstable angina, or those taking strong CYP3A4 inhibitors. A healthcare professional should evaluate suitability before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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