Product image of Lacipil (Lacidipine) supplied by GNH India

Lacipil

Active Ingredient:
Lacidipine
Origin:
EU

Lacipil (Lacidipine)

Lacidipine, the active ingredient in Lacipil, is a calcium channel blocker presented as an oral tablet for oral use. It is indicated for the treatment of hypertension in adult patients, where it helps reduce elevated blood pressure by causing vasodilation of peripheral arteries.

GNH India supplies Lacipil as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide in accordance with EU quality standards. Our global logistics network ensures timely delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Glaxosmithkline (Ireland) Limited

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Indications & Clinical Uses

Lacidipine is a calcium channel blocker used to treat conditions related to high blood pressure.

  • Essential hypertension: lowers systolic and diastolic pressure in adults with primary hypertension.
  • Isolated systolic hypertension: reduces elevated systolic pressure in older patients.
  • Hypertension with cardiovascular disease: assists in blood pressure control as part of combination therapy.

How It Works

  • Lacidipine selectively inhibits L-type calcium channels in vascular smooth muscle cells, decreasing calcium influx. This results in relaxation of arterial smooth muscle, leading to vasodilation and a consequent reduction in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Lacidipine may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate pain often occurring after the first dose.
  • Flushing: transient warmth and redness of the face or neck.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: sensation of light‑headedness, especially when standing quickly.
  • Nausea: mild stomach discomfort or urge to vomit.
  • Tachycardia: increased heart rate.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure that may cause fainting.
  • Angioedema: rapid swelling of the face, lips, tongue, or throat requiring emergency care.
  • Myocardial infarction: rare occurrence of heart attack.
  • Significant liver enzyme elevation: abnormal liver function tests.
  • Life‑threatening allergic reactions: anaphylaxis or severe rash.

Precautions & Warnings

Before initiating therapy, certain precautions should be considered.

  • Blood pressure monitoring: regularly assess to ensure therapeutic response.
  • Liver function assessment: evaluate hepatic status, especially in patients with known liver disease.
  • Elderly patients: start at the lowest effective dose and monitor for hypotension.
  • Concomitant antihypertensives: adjust doses to avoid excessive blood pressure lowering.
  • Heart failure: use with caution and monitor for worsening symptoms.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lacidipine may interact with several medicines.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lacidipine plasma levels.
  • Grapefruit juice: can elevate drug concentration and risk of hypotension.
  • Co‑administration with other potent vasodilators: may cause severe blood pressure drops.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce lacidipine effectiveness.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of renal impairment.
  • Diuretics: may enhance the hypotensive effect and require dose adjustments.

Frequently Asked Questions

Lacipil contains lacidipine, which is prescribed to lower high blood pressure in adult patients. By relaxing the smooth muscle of blood vessels, it helps achieve and maintain target blood pressure levels, reducing the risk of cardiovascular complications associated with hypertension.

Lacidipine blocks L‑type calcium channels in the smooth muscle of arteries. This inhibition reduces calcium entry into the cells, causing the vessels to relax and widen (vasodilation). The resulting decrease in peripheral resistance leads to a reduction in systemic blood pressure.

The dose of Lacipil is individualized by the prescribing clinician based on the patient’s blood pressure, age, kidney and liver function, and response to therapy. The prescriber determines the appropriate strength and dosing schedule for each patient.

Safety data for lacidipine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Lacipil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lacidipine belongs to the dihydropyridine class of calcium channel blockers, similar to amlodipine. Compared with amlodipine, lacidipine has a longer half‑life and may cause less peripheral edema, but both effectively lower blood pressure. Choice between them depends on patient tolerance, comorbidities, and physician preference.

Lacipil should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Lacipil is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water and follow any specific timing instructions given by the healthcare professional.

Serious adverse reactions can include severe hypotension, angioedema (swelling of the face, lips, tongue, or throat), myocardial infarction, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience sudden dizziness, swelling, chest pain, or signs of an allergic reaction.

Lacipil is contraindicated in patients with known hypersensitivity to lacidipine or any component of the formulation, in those with severe aortic stenosis, and in individuals with unstable angina or recent myocardial infarction unless specifically advised by a cardiologist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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