Product image of Lacipil (Lacidipine) supplied by GNH India

Lacipil

Active Ingredient:
Lacidipine
Origin:
EU

Lacipil (Lacidipine)

Lacidipine, the active ingredient in Lacipil, is a calcium channel blocker presented as a tablet for oral use. It reduces high blood pressure by relaxing vascular smooth muscle, and is indicated for the treatment of hypertension in adult patients.

GNH India supplies Lacipil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured products that meet European Union regulatory standards. The company follows stringent Good Distribution Practice and provides reliable logistics for global markets and supports post‑marketing surveillance.

Manufacturer / TM Owner

Glaxosmithkline Trading Services Limited

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Indications & Clinical Uses

  • Lacidipine is used to manage hypertension, a condition characterized by chronically elevated arterial pressure.
  • Hypertension: lowers systolic and diastolic blood pressure, helping to reduce the risk of cardiovascular complications.

How It Works

  • Lacidipine selectively blocks L‑type calcium channels in vascular smooth muscle cells, inhibiting calcium influx that is necessary for muscle contraction. This results in relaxation of arterial smooth muscle, vasodilation, and a consequent reduction in peripheral vascular resistance, which lowers systemic blood pressure. The drug’s high lipophilicity allows prolonged binding to the channel, providing sustained antihypertensive effect. Overall, this mechanism contributes to improved cardiovascular outcomes in patients with hypertension.

Side Effects

Lacidipine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache
  • Flushing
  • Peripheral edema
  • Dizziness
  • Nausea

Serious or Rare Side Effects

  • Severe hypotension
  • Angioedema
  • Hepatic dysfunction
  • Myocardial infarction

Precautions & Warnings

  • When prescribing lacidipine, clinicians should consider several safety precautions to minimize risk.
  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Hepatic impairment: use with caution and consider dose adjustment.
  • Elderly patients: start at low dose and monitor for dizziness.
  • Concomitant antihypertensives: evaluate for additive blood pressure lowering effects.
  • Hypersensitivity: discontinue if allergic reaction occurs.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lacidipine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lacidipine plasma levels, risking toxicity.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce effectiveness by lowering drug concentrations.
  • Other potent vasodilators (e.g., nitroglycerin): can cause additive hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may enhance blood pressure lowering effect, requiring dose adjustments.
  • Diuretics: combined use may increase risk of electrolyte imbalance and hypotension.
  • Grapefruit juice: can modestly raise lacidipine levels, advise patients to limit consumption.

Frequently Asked Questions

Lacipil contains lacidipine, which is prescribed to lower elevated blood pressure in adults diagnosed with hypertension. By reducing systemic vascular resistance, it helps prevent complications such as stroke, heart attack, and kidney damage associated with uncontrolled high blood pressure.

Lacidipine blocks L‑type calcium channels on vascular smooth‑muscle cells, preventing calcium entry that triggers contraction. The resulting smooth‑muscle relaxation dilates arteries, decreases peripheral resistance, and lowers arterial pressure, providing a sustained antihypertensive effect.

The dosage of Lacipil is individualized by the prescribing clinician based on the patient’s blood‑pressure profile, age, renal and hepatic function, and concomitant therapies. The prescriber determines the appropriate strength and titration schedule.

Safety data for lacidipine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and alternative therapies are preferred when possible.

To request Lacipil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lacipil belongs to the calcium‑channel‑blocker class, offering potent vasodilation with a long‑acting profile. Compared with beta‑blockers or ACE inhibitors, it may be preferred in patients with asthma or certain metabolic conditions, but drug choice depends on individual comorbidities, tolerability, and physician judgment.

Lacipil tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid exposure to extreme temperatures or humidity.

Lacipil is taken orally, usually once daily with or without food, as directed by the prescribing healthcare professional. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious adverse events, although rare, include severe hypotension, angioedema, hepatic dysfunction, and myocardial infarction. Patients should be educated to seek immediate medical attention if they experience sudden swelling of the face or throat, marked dizziness, chest pain, or signs of liver injury.

Lacipil is contraindicated in individuals with known hypersensitivity to lacidipine or any component of the formulation. It should also be avoided in patients with severe hepatic impairment, unstable angina, or those taking drugs that strongly inhibit CYP3A4 without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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