Product image of Lacipil (Lacidipine) supplied by GNH India

Lacipil

Active Ingredient:
Lacidipine
Origin:
EU

Lacipil (Lacidipine)

Lacidipine, the active ingredient in Lacipil, is a calcium channel blocker presented as a tablet for oral use. It belongs to the dihydropyridine class and is prescribed to lower elevated blood pressure in adult patients with hypertension through vascular smooth muscle relaxation.

GNH India supplies Lacipil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide with a focus on quality assurance, regulatory compliance and reliable delivery across global markets. Our supply chain adheres to stringent standards to ensure product integrity from manufacturing to end‑user.

Manufacturer / TM Owner

Glaxosmithkline, S.A.

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Indications & Clinical Uses

Lacidipine acts on the calcium‑channel pathway to manage high blood pressure.

  • Hypertension: Reduces systolic and diastolic blood pressure in patients with primary hypertension.
  • Essential hypertension: Provides long‑acting blood pressure control when other agents are insufficient.
  • Isolated systolic hypertension: Lowers elevated systolic pressure in older adults.

How It Works

  • Lacidipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells, inhibiting calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation and a consequent reduction in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Adverse reactions may occur with Lacipil use.

Common Side Effects

  • Headache: Mild to moderate intensity.
  • Flushing: Transient warmth and redness of the skin.
  • Peripheral edema: Swelling of the ankles or lower legs.
  • Dizziness: Especially upon standing quickly.

Serious or Rare Side Effects

  • Severe hypotension: Marked drop in blood pressure requiring medical attention.
  • Angio‑edema: Swelling of the face, lips, or throat.
  • Hepatic dysfunction: Elevated liver enzymes or jaundice.

Precautions & Warnings

Before prescribing Lacipil, clinicians should consider several safety aspects.

  • Concomitant antihypertensives: Monitor for additive blood‑pressure lowering effects.
  • Cardiovascular disease: Use cautiously in patients with recent myocardial infarction.
  • Liver impairment: Dose adjustment may be required.
  • Elderly patients: Start at the lowest effective dose and titrate slowly.
  • Store at ambient temperature: Keep below 25°C in the original packaging, protected from moisture.

Avoid Interactions

Lacidipine may interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): Can increase lacidipine plasma levels, raising risk of hypotension.
  • Grapefruit juice: Enhances absorption and may lead to excessive blood‑pressure reduction.

Moderate Interactions (Monitor Closely):\n- Other calcium‑channel blockers: May cause additive vasodilatory effects.

  • Beta‑blockers: Combined use can intensify heart‑rate slowing.
  • Diuretics: May increase the risk of electrolyte imbalance and orthostatic hypotension.

Frequently Asked Questions

Lacipil contains lacidipine, a calcium‑channel blocker that is prescribed to lower high blood pressure in adults diagnosed with hypertension. It helps reduce the risk of complications associated with sustained elevated blood pressure.

Lacidipine blocks L‑type calcium channels in the smooth muscle of blood vessels. By preventing calcium entry, it relaxes the arterial walls, causing vasodilation and a decrease in peripheral resistance, which lowers systemic blood pressure.

The appropriate dose of Lacipil is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications. Dosage adjustments are made individually and should follow the prescriber’s instructions.

The safety of lacidipine in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Lacipil, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacidipine belongs to the dihydropyridine class of calcium‑channel blockers, offering once‑daily dosing and a favorable vascular selectivity profile. Compared with beta‑blockers or ACE inhibitors, it primarily reduces peripheral resistance without directly affecting heart rate, making it a useful alternative or add‑on therapy.

Lacipil tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Lacipil is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events, although rare, include severe hypotension, angio‑edema, and hepatic dysfunction. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, or signs of liver injury such as jaundice.

Lacipil is contraindicated in patients with known hypersensitivity to lacidipine or any component of the formulation, and in those with severe aortic stenosis or uncontrolled heart failure. Clinicians should also exercise caution in patients with significant liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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