Product image of Lacirex (Lacidipine) supplied by GNH India

Lacirex

Active Ingredient:
Lacidipine
Origin:
EU

Lacirex (Lacidipine)

Lacidipine, the active ingredient in Lacirex, is a calcium channel blocker presented as an oral dosage form for oral use. It is used to treat hypertension in adult patients.
GNH India supplies Lacirex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratori Guidotti S.P.A.

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Indications & Clinical Uses

Lacidipine is a dihydropyridine calcium channel blocker indicated for the management of high blood pressure.

  • Hypertension: lowers systemic vascular resistance and reduces elevated blood pressure, helping to prevent cardiovascular complications.

How It Works

  • Lacidipine selectively blocks L-type calcium channels in vascular smooth muscle, inhibiting calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation, decreased peripheral resistance, and a consequent reduction in arterial blood pressure.

Side Effects

Lacidipine may be associated with a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the lower limbs.
  • Dizziness: especially upon standing.
  • Nausea: occasional gastrointestinal upset.
  • Tachycardia: increased heart rate.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Angioedema: swelling of face, lips, or throat.
  • Elevated liver enzymes: indicating possible hepatic involvement.
  • Cardiac arrhythmia: irregular heart rhythm.

Precautions & Warnings

When prescribing lacidipine, clinicians should consider several safety measures.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Concomitant antihypertensives: adjust doses to prevent additive blood pressure lowering.
  • Sudden discontinuation: taper gradually to avoid rebound hypertension.
  • Cardiovascular disease: evaluate risk of ischemic events.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lacidipine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lacidipine plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic effect.
  • Concurrent use with other potent vasodilators: risk of severe hypotension.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: additive blood pressure lowering.

  • Diuretics: may enhance orthostatic hypotension.
  • NSAIDs: can blunt antihypertensive response.
  • Grapefruit juice: may modestly raise drug concentrations.
  • Alcohol: can increase dizziness and hypotensive effects.

Frequently Asked Questions

Lacirex contains lacidipine, a calcium channel blocker that is prescribed to lower high blood pressure (hypertension) in adult patients, helping to reduce the risk of cardiovascular events.

Lacidipine blocks L-type calcium channels in the smooth muscle of arteries, preventing calcium entry. This relaxation of vascular smooth muscle leads to vasodilation, decreased peripheral resistance, and a reduction in arterial blood pressure.

The appropriate dose of Lacirex is determined by the prescribing clinician based on the individual’s blood pressure, response to therapy, and any co‑existing medical conditions. Patients should follow the prescriber’s instructions.

Safety data for lacidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Lacirex, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacidipine belongs to the dihydropyridine class of calcium channel blockers, offering potent arterial vasodilation with a once‑daily dosing profile. Compared with beta‑blockers or ACE inhibitors, it may cause fewer metabolic effects but can be associated with peripheral edema.

Lacirex should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain product stability.

Lacirex is taken orally, usually as a tablet, with or without food. The exact administration schedule should follow the prescribing clinician’s directions.

Serious risks include severe hypotension, myocardial infarction, angioedema, significant liver enzyme elevations, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience symptoms such as fainting, chest pain, swelling of the face or throat, or irregular heartbeats.

Lacirex is contraindicated in patients with known hypersensitivity to lacidipine or any component of the formulation, and in those with severe aortic stenosis or uncontrolled heart failure. Clinicians should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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