Product image of Lacopat Packung Zur Behandlungseinleitung (Lacosamide) supplied by GNH India

Lacopat Packung Zur Behandlungseinleitung

Active Ingredient:
Lacosamide
Origin:
EU

Lacopat Packung Zur Behandlungseinleitung (Lacosamide)

Lacosamide, the active ingredient in Lacopat Packung Zur Behandlungseinleitung, is a sodium channel blocker presented as an oral tablet for oral use. It is indicated for the treatment of partial‑onset seizures in patients with epilepsy.

GNH India supplies Lacopat Packung Zur Behandlungseinleitung as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

  • Lacosamide is an antiepileptic medication used in the management of seizure disorders.
  • Partial‑onset seizures (epilepsy): reduces seizure frequency as monotherapy or adjunctive therapy.
  • Adjunctive therapy for refractory focal seizures: added when seizures persist despite other agents.
  • Secondary generalized seizures arising from focal onset: helps prevent progression of seizure activity.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, which stabilizes hyper‑excitable neuronal membranes and reduces repetitive firing. By selectively modulating sodium channel kinetics, it diminishes neuronal excitability that underlies focal seizure generation.

Side Effects

Lacosamide may cause a range of adverse reactions.

Common Side Effects

  • Dizziness
  • Nausea or vomiting
  • Headache
  • Fatigue or somnolence
  • Diplopia (double vision)
  • Ataxia or unsteady gait

Serious or Rare Side Effects

  • Cardiac conduction abnormalities, including PR‑interval prolongation
  • Suicidal ideation or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hypersensitivity reactions including anaphylaxis
  • Hepatic dysfunction or elevated liver enzymes

Precautions & Warnings

  • When prescribing lacosamide, several safety considerations are important.
  • Renal impairment: adjust dose in patients with reduced kidney function.
  • Cardiac monitoring: obtain baseline ECG and monitor for PR‑interval changes.
  • Abrupt discontinuation: taper gradually to avoid seizure worsening.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Hypersensitivity: avoid in individuals with known allergy to lacosamide.
  • Store at ambient temperature: keep in original pack, protect from moisture and excessive heat.

Avoid Interactions

Lacosamide can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole) may increase lacosamide plasma levels.
  • Co‑administration with other sodium‑channel blockers can heighten risk of cardiac conduction delays.
  • Drugs that markedly prolong PR interval should not be combined.

Moderate Interactions (Monitor Closely)

  • Carbamazepine may reduce lacosamide concentrations.
  • Oral contraceptives may become less effective.
  • Alcohol can enhance central nervous system depression.
  • Other antiepileptics may require dose adjustments.
  • Antihypertensive agents may have additive effects on blood pressure.

Frequently Asked Questions

Lacopat Packung Zur Behandlungseinleitung contains lacosamide, which is prescribed for the treatment of partial‑onset seizures in patients with epilepsy. It may be used as a stand‑alone therapy or added to other antiepileptic drugs when seizures are not adequately controlled.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels in neurons. This action stabilises hyper‑excitable neuronal membranes, reduces repetitive firing, and consequently lowers the likelihood of seizure generation, particularly in focal seizure types.

The appropriate dose of Lacopat is determined individually by a qualified prescriber based on the patient’s clinical condition, age, renal function and response to therapy. Healthcare professionals start with a low dose and titrate upward as needed, following approved prescribing guidelines.

Safety data for lacosamide in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required cold‑chain handling) and import documentation.

Lacopat (lacosamide) differs from many traditional antiepileptics such as carbamazepine or phenytoin by selectively enhancing slow inactivation of sodium channels rather than blocking fast inactivation. This mechanism may result in a distinct side‑effect profile, with fewer cognitive effects but a potential for cardiac conduction changes, making it a useful alternative for patients who do not tolerate other agents.

Lacopat should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging to protect them from moisture and light. Do not store in a bathroom or near a heat source, and keep out of reach of children.

Lacopat is taken orally. The tablet should be swallowed whole with a glass of water and can be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare provider and should not crush or chew the tablet unless specifically instructed.

The most serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, which may lead to arrhythmias, as well as psychiatric effects like suicidal thoughts, severe skin reactions (e.g., Stevens‑Johnson syndrome), and hypersensitivity reactions. Patients should be monitored regularly for these events, especially during dose escalation.

Lacopat should be avoided in individuals with a known hypersensitivity to lacosamide or any of its excipients, in patients with significant cardiac conduction disorders (e.g., second‑degree AV block), and in those taking contraindicated medications that markedly prolong the PR interval. A thorough medical review is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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