Product image of Lacosamid Abz (Lacosamide) supplied by GNH India

Lacosamid Abz

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamid Abz (Lacosamide)

Lacosamide, the active ingredient in Lacosamid Abz, is an anti‑epileptic drug presented as an oral formulation for oral use. It is employed as adjunctive therapy to control partial‑onset seizures in patients with epilepsy who require additional seizure control and helps reduce seizure frequency and improve quality of life.

GNH India supplies Lacosamid Abz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance for global distribution to meet the therapeutic needs of patients with refractory epilepsy.

Manufacturer / TM Owner

Abz-Pharma Gmbh

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Indications & Clinical Uses

  • Lacosamide is an anti‑epileptic agent indicated for the management of focal seizure disorders.
  • Partial‑onset seizures: added to existing therapy to lower seizure frequency and improve seizure control in patients with focal epilepsy.
  • Focal seizures: employed as adjunctive treatment to enhance overall seizure management when monotherapy is insufficient.
  • Refractory epilepsy: used as part of combination therapy to achieve better seizure control in patients who have not responded adequately to other medications.
  • Adjunctive therapy in epilepsy: contributes to overall reduction of seizure burden when combined with other antiepileptic drugs.

How It Works

  • Lacosamide selectively enhances the slow inactivation phase of voltage‑gated sodium channels in neuronal membranes. By stabilizing hyper‑excitable neuronal tissue, it reduces the ability of neurons to fire repetitively, thereby diminishing the propagation of epileptic discharges. This action is distinct from classic sodium‑channel blockers that affect fast inactivation, providing a complementary mechanism when combined with other antiepileptic agents and contributes to seizure control.

Side Effects

Lacosamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue
  • Blurred vision
  • Tremor

Serious or Rare Side Effects

  • Cardiac arrhythmia (PR interval prolongation)
  • Suicidal thoughts or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hypersensitivity reactions including rash and angioedema
  • Elevated liver enzymes indicating possible hepatic injury

Precautions & Warnings

When prescribing Lacosamide, several safety considerations should be observed.

  • Renal impairment: dose may need adjustment and renal function should be monitored.
  • Hepatic impairment: monitor liver function tests regularly.
  • Cardiac conduction disorders: avoid use in patients with pre‑existing PR‑interval prolongation.
  • Pregnancy: risk unknown; use only if potential benefit justifies the potential risk to the fetus.
  • Concomitant CNS depressants: may increase dizziness and somnolence.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP2C19 inhibitors (e.g., fluconazole) may increase lacosamide plasma concentrations.
  • Drugs that prolong the PR interval (e.g., class IA anti‑arrhythmics) can heighten the risk of cardiac conduction abnormalities.

Moderate Interactions (Monitor Closely)

  • Enzyme inducers such as carbamazepine may reduce lacosamide levels.
  • Other antiepileptic drugs (e.g., valproate) may require therapeutic monitoring.
  • Alcohol consumption may enhance central nervous system depression.

Frequently Asked Questions

Lacosamid Abz contains lacosamide, which is prescribed as an adjunctive treatment for partial‑onset (focal) seizures in patients with epilepsy. It is added to existing antiepileptic regimens when seizure control is not adequate with a single medication.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neurons. This stabilises hyper‑excitable neuronal membranes, reducing repetitive firing and the spread of epileptic discharges, thereby helping to control seizures.

The specific dose of Lacosamid Abz is determined by the prescribing clinician based on the patient’s clinical condition, age, renal and hepatic function, and response to therapy. No fixed regimen is provided here.

Safety data for lacosamide in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide’s mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional agents that block fast inactivation. This can provide complementary seizure control when combined with drugs such as carbamazepine or levetiracetam, and it may have a distinct side‑effect profile.

Store the product at room temperature, below 25 °C, in its original packaging. Protect it from moisture, excessive heat and direct sunlight to maintain stability and potency throughout its shelf life.

Lacosamid Abz is taken orally. The tablets should be swallowed whole with water and may be taken with or without food, as directed by the prescribing physician.

Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation, suicidal ideation or behavior, severe skin reactions like Stevens‑Johnson syndrome, and significant liver enzyme elevations. Patients should be monitored closely for these conditions.

Patients with known hypersensitivity to lacosamide or any of its excipients, those with pre‑existing PR‑interval prolongation, or individuals with severe cardiac conduction disorders should avoid using Lacosamid Abz. Contra‑indications should be confirmed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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