Product image of Lacosamid Al (Lacosamide) supplied by GNH India

Lacosamid Al

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamid Al (Lacosamide)

Lacosamide, the active ingredient in Lacosamid Al, is an anticonvulsant presented as an oral formulation for oral use. It treats partial‑onset seizures and epilepsy in adults and children.

GNH India supplies Lacosamid Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Lacosamide is used as an adjunctive therapy for seizure disorders, acting on neuronal excitability to reduce seizure frequency.

  • Partial‑onset seizures: decreases the number of seizures experienced by patients.
  • Focal epilepsy: provides adjunctive control of focal seizure activity.
  • Refractory focal seizures: offers an additional option when other antiepileptics are insufficient.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyperexcitable neuronal membranes and thereby reducing the likelihood of repetitive firing that leads to seizure activity.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness
  • Nausea
  • Fatigue
  • Headache

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or other severe skin reactions
  • Cardiac arrhythmia, including PR‑interval prolongation
  • Suicidal thoughts or behavior

Precautions & Warnings

Before initiating therapy, several safety considerations should be reviewed.

  • Renal impairment: assess renal function and adjust dose if necessary.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Concomitant CNS depressants: may increase sedation; observe patient closely.
  • History of cardiac arrhythmia: obtain baseline ECG and monitor periodically.
  • Pregnancy: use only when the potential benefit justifies the potential risk to the fetus.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Lacosamide can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: may lower lacosamide plasma concentrations.
  • Phenytoin: may reduce lacosamide levels.
  • Primidone: may decrease lacosamide exposure.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): may enhance sedation.
  • Alcohol: can increase central nervous system effects.
  • Antidepressants (e.g., SSRIs): monitor for increased dizziness or somnolence.

Frequently Asked Questions

Lacosamid Al contains lacosamide, an anticonvulsant indicated for the adjunctive treatment of partial‑onset seizures and focal epilepsy in patients who require additional seizure control.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing hyperexcitable neuronal membranes and reducing the likelihood of repetitive firing that leads to seizures.

The prescribed dose of Lacosamid Al is determined by the treating physician based on the patient’s clinical condition, age, renal function, and response to therapy. Dosage adjustments are individualized.

Safety data in pregnancy and lactation are limited. Lacosamide should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the prescriber.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that target fast inactivation. This can provide complementary seizure control when added to other agents, and it is generally well tolerated compared with some older drugs.

Store Lacosamid Al at ambient temperature below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Do not refrigerate or freeze the product.

Lacosamid Al is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, cardiac arrhythmias (especially PR‑interval prolongation), and the emergence of suicidal thoughts or behavior. Patients should be monitored closely for these events.

Patients with known hypersensitivity to lacosamide or any component of the formulation should avoid it. Caution is also advised for individuals with significant cardiac conduction disorders, severe hepatic impairment, or uncontrolled renal disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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