Product image of Lacosamid Hikma (Lacosamide) supplied by GNH India

Lacosamid Hikma

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamid Hikma (Lacosamide)

Lacosamide, the active ingredient in Lacosamid Hikma, is an anticonvulsant presented as an intravenous solution for parenteral use. Approved in the EU, it is indicated for the treatment of partial onset seizures in patients with epilepsy, reducing seizure frequency and severity by stabilizing neuronal membranes.\n\nGNH India supplies Lacosamid Hikma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and pharmacies worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Hikma Farmacêutica (Portugal), S.A.

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Indications & Clinical Uses

  • Lacosamid Hikma is an anticonvulsant used in the management of focal seizure disorders.\n\nPartial onset seizures: reduces seizure frequency and severity.\nEpilepsy (adjunctive therapy): improves overall seizure control when added to existing regimens.\nFocal epilepsy: provides additional seizure reduction as part of combination therapy.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing the inactive state of these channels, it diminishes repetitive neuronal firing and hyperexcitability, thereby decreasing the likelihood of seizure propagation.

Side Effects

  • Common Side Effects:\n- Dizziness\n- Nausea\n- Fatigue\n- Headache\n\nSerious or Rare Side Effects:\n- Cardiac conduction abnormalities (e.g., PR interval prolongation)\n- Atrial fibrillation\n- Severe skin reactions such as Stevens‑Johnson syndrome\n- Suicidal ideation or behavior

Precautions & Warnings

  • Lacosamid Hikma requires careful clinical monitoring in several situations.\n\nRenal impairment: adjust dosing and monitor renal function.\nCardiac disease: obtain baseline ECG and watch for PR prolongation.\nPregnancy: use only when potential benefit justifies the risk to the fetus.\nConcomitant antiepileptics: monitor for additive central nervous system depression.\nElderly patients: initiate at lower dose and titrate cautiously.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Lacosamid Hikma may interact with several medications that affect cardiac conduction or drug metabolism.\n\nMajor Interactions (Avoid):\n- Class I antiarrhythmics (e.g., quinidine): increase risk of PR prolongation.\n- Carbamazepine: may lower lacosamide plasma concentrations.\n- Strong CYP2C19 inhibitors (e.g., fluconazole): can raise lacosamide exposure.\n- Other sodium‑channel blockers (e.g., phenytoin): additive CNS effects.\n\nModerate Interactions (Monitor Closely):\n- Alcohol: may enhance dizziness and sedation.\n- Valproate: monitor efficacy and possible increased side effects.\n- Loop diuretics (e.g., furosemide): watch electrolyte balance and cardiac parameters.

Frequently Asked Questions

Lacosamid Hikma is used as an adjunctive therapy for the treatment of partial (focal) onset seizures in patients with epilepsy. It helps to lower seizure frequency and severity when added to a patient’s existing antiepileptic regimen.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and reducing repetitive neuronal firing. This mechanism diminishes hyperexcitability in the brain, which is a key factor in seizure generation.

The specific dose of Lacosamid Hikma is determined by the prescribing clinician based on the patient’s clinical condition, age, renal function, and concomitant therapies. Dosage adjustments are made to achieve optimal seizure control while minimizing side effects.

Safety data in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Lacosamide differs from many traditional antiepileptics by selectively enhancing slow sodium‑channel inactivation, which may result in fewer cognitive side effects compared with drugs like carbamazepine or phenytoin. Its intravenous formulation also offers rapid onset for acute seizure management.

Lacosamid Hikma should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Prior to administration, inspect the solution for particulate matter and ensure the vial is within its expiry date.

The product is supplied as an intravenous solution and is administered by slow infusion under the supervision of a qualified healthcare professional. The infusion rate and total daily dose are individualized by the prescriber based on therapeutic response.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, atrial fibrillation, severe skin reactions (e.g., Stevens‑Johnson syndrome), and emergence of suicidal thoughts or behaviors. Prompt medical evaluation is required if any of these events occur.

Patients with known hypersensitivity to lacosamide or any component of the formulation should avoid use. Caution is also advised for individuals with significant cardiac disease, severe renal impairment, or those taking interacting medications that may increase cardiac risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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