Product image of Lacosamid Intas (Lacosamide) supplied by GNH India

Lacosamid Intas

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamid Intas (Lacosamide)

Lacosamide, the active ingredient in Lacosamid Intas, is a sodium channel blocker presented as an oral tablet for oral use. It is indicated as adjunctive therapy for partial‑onset seizures in patients with epilepsy. By modulating neuronal excitability, it helps reduce seizure frequency and improve seizure control.

GNH India supplies Lacosamid Intas as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance. Our distribution network ensures timely delivery across Europe, Asia, Africa and the Americas.

Manufacturer / TM Owner

Intas Third Party Sales 2005, S.L.

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Indications & Clinical Uses

  • Lacosamid Intas is a sodium channel‑blocking antiepileptic used as adjunctive therapy for focal seizure disorders.
  • Partial‑onset seizures: reduces seizure frequency when added to existing antiepileptic regimens.
  • Focal seizures: improves overall seizure control as a supplemental treatment.
  • Epilepsy (partial seizures): contributes to better management of seizure burden in patients with refractory epilepsy.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyperexcitable neurons and decreasing repetitive firing. This modulation of sodium channel kinetics reduces the likelihood of seizure propagation and helps maintain normal neuronal activity.

Side Effects

Common Side Effects

  • Dizziness
  • Nausea
  • Fatigue
  • Headache

Serious or Rare Side Effects

  • Cardiac conduction abnormalities such as PR‑interval prolongation
  • Severe skin reactions, including Stevens‑Johnson syndrome
  • Suicidal thoughts or behaviors

Precautions & Warnings

  • Renal impairment: monitor renal function and adjust therapy as clinically indicated.
  • Hepatic impairment: use with caution and observe liver function tests.
  • Cardiac disease: evaluate baseline ECG and monitor for conduction changes.
  • Pregnancy: risk unknown; weigh potential benefits against risks before prescribing.
  • Drug interactions: review concomitant medications for possible pharmacodynamic or pharmacokinetic effects.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamid Intas may interact with other medications affecting neuronal excitability or cardiac conduction.

Major Interactions (Avoid)

  • Co‑administration with other sodium‑channel blockers may increase CNS depression risk.
  • Use with drugs that prolong PR interval (e.g., certain antiarrhythmics) can exacerbate cardiac conduction effects.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inducers may reduce lacosamide plasma concentrations.
  • Concomitant alcohol use may enhance dizziness and somnolence.
  • Combination with other antiepileptics may require therapeutic drug monitoring.

Frequently Asked Questions

Lacosamid Intas contains the active ingredient lacosamide, which is prescribed as an adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy. It is added to existing antiepileptic regimens to help reduce seizure frequency and improve overall seizure control.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing hyperexcitable neurons, it reduces repetitive firing and the spread of seizure activity, thereby contributing to seizure suppression.

The specific dose of Lacosamid Intas is determined by the prescribing healthcare professional based on the individual patient's condition, response, and tolerability. Dosing information should be obtained from the prescriber’s instructions and the product labeling.

The safety of lacosamide in pregnancy and lactation has not been fully established. Clinicians should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing women, and discuss alternative options when appropriate.

To request Lacosamid Intas, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacosamide belongs to the sodium channel blocker class, offering a distinct mechanism that enhances slow inactivation of sodium channels. Compared with other antiepileptics that act on fast inactivation or other pathways, lacosamide may provide complementary seizure control when used as add‑on therapy, especially in patients with refractory focal seizures.

Lacosamid Intas should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lacosamid Intas is administered orally, typically as a tablet taken with or without food. The exact administration schedule and any special instructions should follow the prescribing clinician’s guidance and the product’s labeling.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and the emergence of suicidal thoughts or behaviors. Patients should be monitored for these events, and any concerning symptoms should prompt immediate medical evaluation.

Lacosamid Intas is contraindicated in patients with known hypersensitivity to lacosamide or any of its excipients. Caution is advised for individuals with significant cardiac conduction disorders, uncontrolled arrhythmias, or those taking other medications that markedly affect sodium channel function.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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