Product image of Lacosamid Mylan (Lacosamide) supplied by GNH India

Lacosamid Mylan

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamid Mylan (Lacosamide)

Lacosamide, the active ingredient in Lacosamid Mylan, is an anti‑epileptic (sodium channel modifier) presented as an oral dosage form for oral use. It is indicated as adjunctive therapy for partial‑onset seizures in patients with epilepsy.
GNH India supplies Lacosamid Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan Germany Gmbh

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Indications & Clinical Uses

Lacosamide is an anti‑epileptic that targets focal seizure activity.

  • Partial‑onset seizures in adults: Reduces seizure frequency as add‑on therapy.
  • Partial‑onset seizures in children (≥4 years): Provides adjunctive seizure control in pediatric patients.
  • Focal seizures refractory to other agents: Offers an alternative mechanism of action for patients not responding to standard treatments.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and reducing hyper‑excitability. It may also bind to the collapsin response mediator protein‑2 (CRMP2), further modulating neuronal firing and contributing to its anticonvulsant effect.

Side Effects

Lacosamide may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: Transient sensation of light‑headedness.
  • Fatigue: Generalized tiredness or lack of energy.
  • Nausea: Mild to moderate upset stomach.
  • Diplopia: Blurred or double vision.
  • Headache: Mild to moderate cranial pain.
  • Somnolence: Increased sleepiness.

Serious or Rare Side Effects

  • Suicidal ideation: Emergence of thoughts of self‑harm.
  • Severe skin reactions: Including Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac conduction abnormalities: PR‑interval prolongation that may lead to arrhythmias.
  • Severe allergic reactions: Anaphylaxis or angioedema.
  • Hepatic injury: Elevated liver enzymes or liver dysfunction.

Precautions & Warnings

When prescribing Lacosamide, clinicians should consider several safety measures.

  • Monitor seizure control: Adjust dose under medical supervision to achieve optimal efficacy.
  • Assess renal function: Dose may need modification in patients with impaired renal clearance.
  • Check cardiac conduction: Baseline ECG recommended due to potential PR‑interval effects.
  • Avoid abrupt discontinuation: Taper the medication to prevent seizure worsening.
  • Store at room temperature: Keep in the original container, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine): May markedly reduce lacosamide exposure.
  • Drugs that prolong PR interval (e.g., quinidine): Increase risk of cardiac conduction delay.
  • Concurrent sodium channel blockers (e.g., phenytoin): May heighten toxicity.

Moderate Interactions (Monitor Closely)

  • Other antiepileptic drugs: May require dose adjustments based on therapeutic response.
  • Oral contraceptives: Lacosamide can diminish hormonal efficacy, necessitating alternative contraception.
  • Alcohol: Combined use may enhance central nervous system depression and dizziness.

Frequently Asked Questions

Lacosamid Mylan contains lacosamide, which is prescribed as an adjunctive treatment for partial‑onset (focal) seizures in patients with epilepsy. It is used when seizures are not fully controlled by a single antiepileptic medication, helping to reduce seizure frequency and improve overall seizure management.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels in neuronal membranes, which stabilizes hyper‑excitable neurons and reduces the likelihood of seizure firing. It may also interact with the CRMP2 protein, further modulating neuronal excitability and contributing to its anticonvulsant properties.

The specific dose of Lacosamid Mylan is determined by the prescribing clinician based on the individual’s age, weight, renal function, and response to therapy. Typically, treatment starts with a low dose that is gradually increased to achieve optimal seizure control while minimizing side effects.

Safety data for lacosamide in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lacosamid Mylan. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Lacosamide offers a distinct mechanism by enhancing slow sodium‑channel inactivation, unlike many older agents that target fast inactivation. Compared with drugs such as carbamazepine or phenytoin, lacosamide may have a lower risk of certain drug‑enzyme interactions and a different side‑effect profile, making it a useful alternative for patients who do not tolerate or respond to traditional sodium‑channel blockers.

Lacosamid Mylan should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid exposing it to extreme temperatures or humidity, which could affect its stability.

Lacosamid Mylan is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. The medication should be swallowed whole with a glass of water and taken at the same times each day to maintain consistent blood levels.

Serious risks include the potential for suicidal thoughts or behavior, severe skin reactions such as Stevens‑Johnson syndrome, cardiac conduction abnormalities like PR‑interval prolongation, and rare cases of severe allergic reactions or liver injury. Patients should be monitored closely for any new or worsening symptoms and seek immediate medical attention if serious adverse events occur.

Lacosamid Mylan is contraindicated in individuals with known hypersensitivity to lacosamide or any of its excipients. Caution is advised for patients with significant cardiac conduction disorders, severe renal impairment, or those taking medications that markedly prolong the PR interval. Pregnant or breastfeeding women should only use it when clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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