Product image of Lacosamid Ratiopharm (Lacosamide) supplied by GNH India

Lacosamid Ratiopharm

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamid Ratiopharm (Lacosamide)

Lacosamide, the active ingredient in Lacosamid Ratiopharm, is a sodium channel blocker presented as an oral tablet for oral use. It works by enhancing the slow inactivation of voltage‑gated sodium channels, stabilising hyper‑excitable neuronal membranes, and is prescribed as adjunctive therapy to reduce the frequency of partial‑onset (focal) seizures in patients with epilepsy.

GNH India supplies Lacosamid Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable global distribution.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lacosamide is indicated for focal seizure disorders and is used as part of an adjunctive treatment regimen in epilepsy.

  • Partial-onset (focal) seizures: reduces seizure frequency when added to existing antiepileptic therapy.
  • Refractory focal epilepsy: provides additional seizure control for patients not adequately managed by other medications.
  • Adjunctive therapy in epilepsy: used alongside other antiepileptic drugs to improve overall seizure management.

How It Works

  • Lacosamide selectively enhances the slow inactivation phase of voltage‑gated sodium channels in neuronal membranes. By stabilising the inactive state of these channels, it reduces repetitive neuronal firing and diminishes hyper‑excitability that underlies seizure activity. This targeted action does not significantly affect the fast inactivation process, allowing normal neuronal function while preventing the propagation of epileptic discharges.

Side Effects

Lacosamide may cause a range of adverse reactions, which are categorised by frequency and severity.

Common Side Effects

  • Dizziness
  • Nausea
  • Headache
  • Fatigue
  • Diplopia
  • Somnolence

Serious or Rare Side Effects

  • Cardiac conduction abnormalities (e.g., PR‑interval prolongation)
  • Suicidal thoughts or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hepatic dysfunction
  • Hypersensitivity reactions including anaphylaxis
  • Blood dyscrasias (e.g., agranulocytosis)

Precautions & Warnings

When prescribing Lacosamide, several safety considerations should be observed.

  • Renal impairment: assess renal function and adjust dose if necessary.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Cardiac conduction: obtain baseline ECG and monitor for PR‑interval changes.
  • Pregnancy: risk unknown; use only if potential benefit justifies potential risk.
  • Concomitant antiepileptic drugs: evaluate for possible efficacy or interaction issues.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with other medicines, requiring attention to the level of interaction.

Major Interactions (Avoid)

  • Carbamazepine: induces metabolism, markedly reducing lacosamide plasma levels.
  • Phenytoin: induces metabolism, leading to decreased lacosamide exposure.
  • Strong CYP2C19 inhibitors (e.g., fluconazole): increase lacosamide concentrations and risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance central nervous system depression and dizziness.
  • Other antiepileptics (valproate, levetiracetam): may require dose adjustments based on seizure control.
  • Hormonal contraceptives: lacosamide may reduce contraceptive effectiveness; consider alternative methods.

Frequently Asked Questions

Lacosamid Ratiopharm contains lacosamide, an antiepileptic drug prescribed as adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy. It is added to existing seizure‑control regimens to help reduce seizure frequency and improve overall seizure management.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilising these channels in an inactive state, it limits repetitive neuronal firing and reduces hyper‑excitability, which are key mechanisms underlying seizure generation.

The specific dose of Lacosamid Ratiopharm is determined by the prescribing clinician based on the patient’s age, renal and hepatic function, and response to therapy. Dosage adjustments are made individually; no fixed regimen is provided in public information.

Safety data for lacosamide during pregnancy and lactation are limited. The drug should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lacosamide belongs to the sodium‑channel blocker class and is distinguished by its selective enhancement of slow channel inactivation. Compared with older sodium‑channel blockers such as carbamazepine, lacosamide has a different interaction profile and may be better tolerated in some patients, but individual response varies and choice depends on clinical factors.

Lacosamid Ratiopharm should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat and direct light to maintain potency throughout its shelf life.

Lacosamid Ratiopharm is taken orally, usually as a tablet. It is swallowed whole with water and can be taken with or without food, following the dosing schedule prescribed by the treating physician.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, suicidal ideation or behavior, severe skin reactions (e.g., Stevens‑Johnson syndrome), hepatic dysfunction, hypersensitivity reactions including anaphylaxis, and rare blood disorders like agranulocytosis. Patients should be monitored for these events.

Lacosamid is contraindicated in patients with known hypersensitivity to lacosamide or any component of the formulation. Caution is advised for individuals with significant cardiac conduction disorders, severe hepatic impairment, or those taking strong enzyme‑inducing antiepileptics that markedly reduce lacosamide levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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