Product image of Lacosamid Stada (Lacosamide) supplied by GNH India

Lacosamid Stada

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamid Stada (Lacosamide)

Lacosamide, the active ingredient in Lacosamid Stada, is a sodium channel blocker presented as an oral formulation for oral use. It is used as adjunctive therapy for partial‑onset seizures in patients with epilepsy.
GNH India supplies Lacosamid Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Gmbh

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Indications & Clinical Uses

  • Lacosamide is an antiepileptic medication that targets voltage‑gated sodium channels to control seizures.
  • Partial‑onset seizures: adjunctive therapy to reduce seizure frequency in patients with epilepsy.
  • Focal seizures: improves seizure control in individuals with focal epilepsy.
  • Epilepsy: used as part of combination therapy for overall seizure management.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing hyper‑excitable neuronal membranes and reducing repetitive neuronal firing, which helps to diminish seizure activity in the central nervous system.

Side Effects

Lacosamide may cause a range of adverse reactions, some of which are more frequent than others.

Common Side Effects

  • Dizziness
  • Fatigue
  • Nausea
  • Headache
  • Diplopia (double vision)
  • Somnolence

Serious or Rare Side Effects

  • Cardiac conduction abnormalities (e.g., PR‑interval prolongation)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Suicidal thoughts or behavior
  • Hypersensitivity reactions including anaphylaxis
  • Hepatic injury
  • Aseptic meningitis

Precautions & Warnings

  • When prescribing Lacosamide, several safety considerations should be observed.
  • Dose titration: start with a low dose and increase gradually as directed by the prescriber.
  • Renal impairment: assess renal function and adjust dosing if necessary.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Concomitant CNS depressants: may increase sedation and dizziness.
  • Pregnancy: risk unknown; use only if potential benefit justifies the risk.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lacosamide can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: may lower lacosamide plasma concentrations.
  • Phenytoin: can reduce lacosamide exposure.
  • Rifampin: may decrease lacosamide levels.
  • Strong CYP3A4 inhibitors: may raise lacosamide concentrations.
  • Drugs that prolong PR interval: increase risk of cardiac conduction effects.

Moderate Interactions (Monitor Closely)

  • Other antiepileptic drugs: additive CNS depression may occur.
  • Alcohol: can enhance sedative effects.
  • Opioids: may increase risk of respiratory depression.

Frequently Asked Questions

Lacosamid Stada contains lacosamide, which is prescribed as an adjunctive treatment for partial‑onset seizures in patients with epilepsy. It helps reduce the frequency of seizures when used together with other antiepileptic drugs.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This stabilizes hyper‑excitable neurons, limits repetitive firing, and thereby diminishes the likelihood of seizure propagation.

The exact dose is determined by the prescribing clinician based on the patient’s age, weight, renal function, and response to therapy. Typical dosing starts low and is gradually increased to achieve optimal seizure control while monitoring tolerability.

Safety data for lacosamide in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow inactivation of sodium channels—differs from agents like carbamazepine that target fast inactivation. It is generally well tolerated and may be preferred for patients who experience side effects with other sodium‑channel blockers, though individual response varies.

Lacosamid Stada should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture. Keep the product out of direct sunlight and out of reach of children.

Lacosamide is taken orally, usually as tablets or oral solution. The medication should be swallowed whole with water and taken at the same times each day to maintain consistent blood levels.

Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, suicidal thoughts or behaviors, hypersensitivity reactions, and rare cases of hepatic injury. Prompt medical attention is required if any of these occur.

Lacosamide is contraindicated in patients with known hypersensitivity to the drug, those with severe cardiac conduction disorders (e.g., second‑ or third‑degree AV block without a pacemaker), and individuals for whom the risk of seizure worsening outweighs potential benefits. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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