Product image of Lacosamid Stada (Lacosamide) supplied by GNH India

Lacosamid Stada

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamid Stada (Lacosamide)

Lacosamide, the active ingredient in Lacosamid Stada, is an anticonvulsant presented as a tablet for oral use. It treats partial-onset seizures in patients with focal epilepsy.

GNH India supplies Lacosamid Stada as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stadapharm Gmbh

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Indications & Clinical Uses

  • Lacosamide is used in the management of focal epilepsy and related seizure disorders.
  • Partial-onset seizures: reduces seizure frequency as monotherapy or add‑on therapy.
  • Adjunctive therapy in epilepsy: combined with other antiepileptic drugs to improve seizure control.
  • Focal epilepsy: helps control seizures originating from a specific brain region.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyper‑excitable neuronal membranes and reducing repetitive neuronal firing that underlies seizure activity. This selective modulation limits the propagation of abnormal electrical impulses without markedly affecting normal neuronal function.

Side Effects

Lacosamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Nausea
  • Headache
  • Fatigue
  • Blurred vision
  • Coordination problems

Serious or Rare Side Effects

  • Cardiac arrhythmias (e.g., PR interval prolongation)
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Suicidal thoughts or behavior
  • Liver enzyme elevations
  • Hypersensitivity reactions (e.g., anaphylaxis)

Precautions & Warnings

When prescribing Lacosamide, consider the following precautions to ensure safe use.

  • Renal impairment: assess kidney function and adjust dose if necessary.
  • Hepatic impairment: monitor liver function and consider dose modification.
  • Cardiac conduction disorders: avoid in patients with known PR interval prolongation.
  • Pregnancy: risk unknown, use only if benefits outweigh risks.
  • Concomitant sodium channel blockers: monitor for additive effects on cardiac conduction.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with other medicines; notable interactions include:

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine): may cause severe cardiac conduction disturbances.
  • Other sodium channel blockers (e.g., carbamazepine, phenytoin): increase risk of arrhythmias.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): raise lacosamide plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluconazole): may modestly increase levels.
  • CYP2C19 inducers (e.g., rifampin): may reduce efficacy.
  • Concomitant use with other antiepileptics (e.g., valproate): monitor seizure control and side effects.

Frequently Asked Questions

Lacosamid Stada contains lacosamide, which is indicated for the treatment of partial‑onset (focal) seizures in patients with epilepsy. It is used either as monotherapy or as an add‑on medication when seizures are not adequately controlled by other antiepileptic drugs.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neurons. By stabilizing hyper‑excitable neuronal membranes, it reduces the repetitive firing of neurons that can trigger seizure activity, thereby helping to control focal seizures.

The exact dose of lacosamide is individualized by the prescribing clinician based on the patient’s age, renal and hepatic function, and response to therapy. The prescriber determines the appropriate starting dose and any subsequent titration schedule.

Safety data for lacosamide during pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To request Lacosamid Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Compared with other sodium‑channel blockers such as carbamazepine, lacosamide selectively enhances slow inactivation rather than fast inactivation, which may result in a different side‑effect profile and lower risk of certain drug‑drug interactions. Clinical choice depends on individual patient characteristics and therapeutic goals.

Lacosamid Stada should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date indicated on the label.

Lacosamid Stada is administered orally as a tablet. The tablet should be swallowed whole with water, preferably with or without food, as directed by the prescribing physician. Patients should follow the dosing schedule provided by their healthcare professional.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, liver enzyme elevations, hypersensitivity reactions, and the emergence of suicidal thoughts or behaviors. Patients should seek immediate medical attention if any of these events occur.

Lacosamid Stada should be avoided in patients with known severe cardiac conduction disorders (e.g., significant PR‑interval prolongation), hypersensitivity to lacosamide or any excipients, and in individuals where the risk of serious adverse reactions outweighs the therapeutic benefit. A thorough medical assessment is required before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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