Product image of Lacosamida Intas (Lacosamide) supplied by GNH India

Lacosamida Intas

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Intas (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Intas, is a sodium channel blocker presented as an oral tablet for oral use. It is indicated for the treatment of partial‑onset seizures in patients with epilepsy. The medication works by stabilizing neuronal membranes and reducing hyperexcitability, helping to control seizure activity.

GNH India supplies Lacosamida Intas as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Intas Third Party Sales 2005, S.L.

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Indications & Clinical Uses

  • Lacosamide is used as an anticonvulsant in the management of seizure disorders.
  • Partial‑onset seizures: reduces frequency and severity of seizures when used as adjunct therapy.
  • Epilepsy: contributes to overall seizure control in patients with focal epilepsy.
  • Adjunctive therapy for refractory focal epilepsy: provides additional seizure reduction when combined with other antiepileptic drugs.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes hyperexcitable neuronal membranes. By prolonging the inactivated state of these channels, it diminishes repetitive neuronal firing and reduces the propagation of epileptiform activity, thereby helping to prevent seizure onset.

Side Effects

Lacosamide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue
  • Blurred vision
  • Diplopia

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Cardiac arrhythmias, including PR‑interval prolongation
  • Suicidal thoughts or behavior
  • Severe hepatic injury
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

When prescribing Lacosamide, clinicians should consider several safety aspects.

  • Renal impairment: adjust dose and monitor renal function.
  • Hepatic impairment: use with caution and monitor liver enzymes.
  • Cardiac conduction abnormalities: obtain baseline ECG and monitor for PR‑interval changes.
  • Pregnancy: safety category unknown; weigh benefits against potential risks.
  • Concomitant use with other sodium channel blockers: increased risk of toxicity.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lacosamide can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin): may lower lacosamide plasma levels.
  • Other sodium channel blockers (e.g., phenytoin, carbamazepine): may increase risk of cardiac and neurologic adverse effects.
  • QT‑prolonging agents: may heighten arrhythmia risk.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce hormonal efficacy.
  • Alcohol: can enhance central nervous system depression.
  • Combination with other antiepileptics: may require dose adjustments based on clinical response.

Frequently Asked Questions

Lacosamida Intas contains lacosamide, which is prescribed to treat partial‑onset seizures and to provide adjunctive therapy for patients with focal epilepsy. It helps reduce seizure frequency and severity when used as part of an individualized antiepileptic regimen.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This action stabilizes hyper‑excitable neurons, limits repetitive firing, and diminishes the spread of epileptiform activity, thereby contributing to seizure control.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, renal and hepatic function, and response to therapy. Initial dosing typically starts low and is titrated upward under medical supervision to achieve optimal seizure control.

Safety data for lacosamide in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Clinicians should evaluate the potential benefits against possible risks and consider alternative therapies when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide differs from many traditional sodium channel blockers such as carbamazepine by selectively enhancing slow inactivation rather than fast inactivation. This mechanism may result in a distinct side‑effect profile and can be advantageous for patients who experience tolerability issues with other agents.

Store the tablets at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date printed on the packaging.

Lacosamida Intas is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless otherwise directed by a healthcare professional.

Serious adverse events include severe skin reactions such as Stevens‑Johnson syndrome, cardiac conduction abnormalities like PR‑interval prolongation, suicidal ideation, significant hepatic injury, and rare blood disorders. Patients should be monitored closely for any of these signs and seek immediate medical attention if they occur.

Lacosamide is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is also advised for individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, and those taking interacting medications that could increase toxicity.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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