Product image of Lacosamida Intas (Lacosamide) supplied by GNH India

Lacosamida Intas

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Intas (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Intas, is a sodium channel blocker presented as an oral tablet for oral use. It treats partial‑onset seizures in adults and adolescents.
GNH India supplies Lacosamida Intas as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Intas Third Party Sales 2005, S.L.

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Indications & Clinical Uses

  • Lacosamide is used to manage seizure disorders that involve abnormal neuronal firing.
  • Partial‑onset seizures: reduces seizure frequency in focal epilepsy.
  • Adjunctive therapy for focal seizures: enhances control when added to existing antiepileptic regimens.
  • Monotherapy for focal epilepsy: may be used alone to manage seizure activity.

How It Works

  • Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing the inactive state of these channels, it diminishes repetitive neuronal firing and reduces hyper‑excitability that underlies seizure generation, without significantly affecting normal neuronal transmission.

Side Effects

Lacosamide may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Dizziness
  • Fatigue
  • Nausea
  • Headache
  • Blurred vision
  • Diplopia

Serious or Rare Side Effects

  • Cardiac conduction abnormalities (e.g., PR‑interval prolongation)
  • Suicidal thoughts or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hypersensitivity reactions including anaphylaxis
  • Elevated liver enzymes
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

  • When prescribing lacosamide, clinicians should consider several safety aspects.
  • Dose adjustment in renal impairment: reduce dose based on renal function.
  • Monitor cardiac conduction in patients with heart disease: check ECG for PR changes.
  • Avoid abrupt discontinuation: taper to prevent seizure worsening.
  • Use caution in hepatic impairment: monitor liver function tests.
  • Pregnancy and breastfeeding: safety unknown, weigh risks and benefits.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Lacosamide can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide plasma levels.
  • Drugs that prolong PR interval (e.g., class IA antiarrhythmics): risk of cardiac conduction delay.
  • Other sodium‑channel blockers (e.g., phenytoin): may enhance CNS depression.

Moderate Interactions (Monitor Closely)

  • Carbamazepine (enzyme inducer): may reduce lacosamide concentrations.
  • Oral contraceptives: potential reduction in contraceptive efficacy.
  • Alcohol or CNS depressants: additive dizziness or sedation.

Frequently Asked Questions

Lacosamida Intas contains lacosamide, which is prescribed to treat partial‑onset (focal) seizures in patients with epilepsy. It helps reduce the frequency and severity of seizure episodes when used alone or as an add‑on to other antiepileptic drugs.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neurons. This stabilises the neuronal membrane, limits repetitive firing, and lowers hyper‑excitability that contributes to seizure generation, providing anticonvulsant effects.

The dosage of Lacosamida Intas is individualized by the prescribing clinician based on the patient’s age, renal function, and therapeutic response. The prescriber determines the appropriate starting dose and titration schedule.

Safety data for lacosamide during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Healthcare providers should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing women.

To request Lacosamida Intas, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide is a sodium‑channel blocker that selectively enhances slow inactivation, differing from many older agents that affect fast inactivation. This mechanism may offer better tolerability for some patients and can be used as monotherapy or adjunctive therapy, providing an alternative to drugs such as carbamazepine or levetiracetam.

Lacosamida Intas should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Lacosamida Intas is taken orally, usually as a tablet, with or without food. The exact administration schedule, including timing and whether it is taken once or twice daily, is determined by the prescribing physician.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, potential suicidal thoughts or behavior, severe skin reactions like Stevens‑Johnson syndrome, and rare blood disorders. Patients should be monitored regularly for these events, especially during dose adjustments.

Lacosamida Intas is contraindicated in patients with known hypersensitivity to lacosamide or any of its excipients. Caution is also advised for individuals with significant cardiac conduction disorders, severe hepatic impairment, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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