Product image of Lacosamida Jubilant Pharmaceuticals (Lacosamide) supplied by GNH India

Lacosamida Jubilant Pharmaceuticals

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Jubilant Pharmaceuticals (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Jubilant Pharmaceuticals, is an anticonvulsant presented as an oral formulation for oral use. It treats partial‑onset seizures in patients with epilepsy.

GNH India supplies Lacosamida Jubilant Pharmaceuticals as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Jubilant Pharmaceuticals Nv

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Indications & Clinical Uses

Lacosamide is an anticonvulsant used in the management of focal seizure disorders.

  • Partial‑onset seizures: reduces seizure frequency in patients with focal epilepsy.
  • Focal epilepsy: provides adjunctive therapy for uncontrolled focal seizures.
  • Refractory epilepsy: used as add‑on treatment when other agents are insufficient.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and decreasing hyper‑excitability. By selectively targeting the persistent sodium current, it limits repetitive neuronal firing without affecting normal channel function, thereby reducing seizure activity in the brain.

Side Effects

Common side effects are generally mild to moderate and may resolve with continued therapy.

Common Side Effects

  • Dizziness
  • Fatigue
  • Nausea
  • Headache
  • Diplopia (double vision)
  • Somnolence

Serious or Rare Side Effects

  • Cardiac arrhythmias (e.g., PR‑interval prolongation)
  • Suicidal ideation or behavior
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Hypersensitivity reactions (rash, angioedema)
  • Hepatic injury
  • Blood dyscrasias (e.g., agranulocytosis)

Precautions & Warnings

Lacosamide requires careful monitoring in several clinical situations.

  • Renal impairment: dose adjustment may be needed.
  • Hepatic impairment: monitor liver function tests.
  • Cardiac conduction abnormalities: obtain baseline ECG and monitor PR interval.
  • Pregnancy: safety category unknown; avoid unless benefit outweighs risk.
  • Concomitant CNS depressants: may increase sedation.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lacosamide can interact with several medicines, requiring dose adjustments or monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide plasma levels.
  • Carbamazepine: may reduce lacosamide exposure, decreasing efficacy.
  • Other sodium‑channel blockers (e.g., phenytoin): increased risk of CNS depression.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance dizziness and somnolence.
  • Additional antiepileptic drugs: monitor seizure control and side‑effect profile.
  • QT‑prolonging agents: observe ECG for interval changes.

Frequently Asked Questions

Lacosamida Jubilant Pharmaceuticals contains lacosamide, an anticonvulsant indicated for the treatment of partial‑onset (focal) seizures in patients with epilepsy, either as monotherapy or as add‑on therapy when seizures are not adequately controlled.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes neuronal membranes and reduces abnormal neuronal firing. This selective action limits the persistence of sodium currents that contribute to seizure generation.

The appropriate dose of lacosamide is determined by the prescribing clinician based on the patient’s age, renal and hepatic function, and response to therapy. Dosage adjustments may be required for special populations.

The safety of lacosamide in pregnancy and lactation has not been fully established. It is classified as having an unknown pregnancy category, so it should only be used if the potential benefit justifies the potential risk to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that block fast sodium channels. This can provide additional seizure control in patients who have not responded to other agents, while offering a generally favorable tolerability profile.

Lacosamida Jubilant Pharmaceuticals should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture. No refrigeration is required for this oral formulation.

Lacosamide is administered orally, typically as tablets or oral solution, and should be taken with or without food as directed by the prescriber. Consistent dosing times help maintain stable blood levels.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, potential suicidal thoughts or behaviors, severe skin reactions like Stevens‑Johnson syndrome, and rare cases of hepatic injury or blood dyscrasias. Patients should be monitored for these events.

Lacosamide is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is also advised for individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, and those taking interacting medications without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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