Product image of Lacosamida Pentafarma (Lacosamide) supplied by GNH India

Lacosamida Pentafarma

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Pentafarma (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Pentafarma, is a sodium channel blocker presented as a tablet for oral use. It is used as adjunctive therapy for partial‑onset seizures in patients with epilepsy.

GNH India supplies Lacosamida Pentafarma as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pentafarma - Sociedade Tecnico-Medicinal S.A.

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Indications & Clinical Uses

  • Lacosamide is an antiepileptic drug indicated for seizure disorders.
  • Partial‑onset seizures: reduces seizure frequency when added to existing antiepileptic regimens.
  • Focal epilepsy: improves overall seizure control as adjunctive therapy.
  • Adjunctive therapy in epilepsy: used together with other agents to achieve better seizure management.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilises hyper‑excitable neuronal membranes and limits repetitive neuronal firing. By selectively targeting the slow inactivation phase, it reduces the likelihood of seizure propagation without markedly affecting normal neuronal activity.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue
  • Somnolence
  • Diplopia

Serious or Rare Side Effects

  • Cardiac arrhythmias (e.g., PR‑interval prolongation)
  • Suicidal thoughts or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hypersensitivity reactions including anaphylaxis
  • Rhabdomyolysis

Precautions & Warnings

When prescribing Lacosamide, clinicians should consider several safety aspects.

  • Renal impairment: evaluate dose adjustments and monitor renal function.
  • Hepatic impairment: use caution and monitor liver enzymes.
  • Cardiac conduction abnormalities: obtain baseline ECG and monitor for PR‑interval changes.
  • Pregnancy: risk category unknown; discuss potential benefits and risks with the patient.
  • Concomitant CNS depressants: monitor for enhanced sedation or respiratory depression.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: induces metabolism, lowering lacosamide plasma levels.
  • Phenytoin: reduces lacosamide concentrations through enzyme induction.
  • Rifampin: markedly decreases lacosamide exposure.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, alcohol): may increase sedation.
  • Other antiepileptics (e.g., valproate): monitor seizure control and side‑effects.
  • Serotonergic agents (e.g., SSRIs, tramadol): risk of serotonin syndrome, observe for symptoms.

Frequently Asked Questions

Lacosamida Pentafarma contains lacosamide, an antiepileptic indicated as adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy. It is prescribed when additional seizure control is needed alongside other antiepileptic medicines.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This stabilises hyper‑excitable neurons, reduces repetitive firing, and helps prevent the spread of seizure activity without significantly affecting normal neuronal function.

The specific dose of Lacosamida Pentafarma is determined by the prescribing clinician based on the patient’s age, renal and hepatic function, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions.

The pregnancy safety category for lacosamide is unknown. It should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Women who are breastfeeding should discuss possible exposure with their healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many older antiepileptics that target fast inactivation. This can provide additive seizure control when combined with other agents and may have a distinct side‑effect profile, such as lower risk of cognitive impairment compared with some alternatives.

Lacosamida Pentafarma should be stored at room temperature, below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

The medication is taken orally, usually as a tablet, with or without food. The exact timing and frequency are set by the prescriber, who may adjust the schedule based on therapeutic response and tolerability.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, potential suicidal thoughts or behaviors, severe skin reactions like Stevens‑Johnson syndrome, hypersensitivity reactions, and rare cases of rhabdomyolysis. Patients should be monitored for these events, especially during treatment initiation.

Patients with known hypersensitivity to lacosamide or any of its excipients should avoid the product. Caution is also advised for individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, and those taking interacting medications that could markedly reduce efficacy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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