Product image of Lacosamida Tarbis (Lacosamide) supplied by GNH India

Lacosamida Tarbis

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Tarbis (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Tarbis, is an anticonvulsant presented as an intravenous solution for intravenous use. It is indicated for the treatment of partial‑onset seizures and is employed as adjunctive therapy in patients with epilepsy. The formulation meets EU regulatory standards and is produced under stringent quality‑control procedures.

GNH India supplies Lacosamida Tarbis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for healthcare providers across multiple markets. The company adheres to Good Distribution Practices and ensures product integrity during transport.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

  • Lacosamide is used in the management of seizure disorders, particularly partial‑onset epilepsy.
  • Partial‑onset seizures: reduces seizure frequency as add‑on therapy.
  • Adjunctive therapy for epilepsy: enhances overall seizure control when combined with other antiepileptic drugs.
  • Focal epilepsy: contributes to comprehensive management of patients with focal seizure types.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyperexcitable neurons and diminishing repetitive firing. This modulation reduces neuronal hyperexcitability associated with seizure activity, providing antiepileptic effects without significantly affecting normal neuronal conduction.

Side Effects

Lacosamide may cause several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Dizziness: mild vertigo or light‑headedness.
  • Nausea: upset stomach or feeling of queasiness.
  • Headache: mild to moderate pain.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Cardiac conduction abnormalities: PR‑interval prolongation or arrhythmias.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Suicidal thoughts: emergence of depressive symptoms or suicidal ideation.

Precautions & Warnings

  • When prescribing Lacosamide, consider the following precautions.
  • Renal impairment: adjust dosing and monitor renal function.
  • Cardiac disease: monitor ECG for PR‑interval changes.
  • Pregnancy: use only if benefits outweigh potential risks.
  • Concomitant CNS depressants: observe for enhanced sedation.
  • Hepatic dysfunction: evaluate liver enzymes.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lacosamide can interact with other medicines; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine): may increase PR‑interval prolongation.
  • Carbamazepine: induces metabolism, reducing lacosamide levels.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise lacosamide exposure.

Moderate Interactions (Monitor Closely)

  • Other antiepileptics (e.g., phenytoin, phenobarbital): may alter seizure control.
  • Opioids: additive central nervous system depression.
  • Alcohol: increased sedation and dizziness.

Frequently Asked Questions

Lacosamida Tarbis contains lacosamide, an anticonvulsant indicated for the treatment of partial‑onset seizures and as adjunctive therapy in patients with epilepsy. It is administered intravenously to help control seizure activity when added to existing antiepileptic regimens.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neurons, stabilizing hyperexcitable membranes and reducing repetitive firing. This mechanism diminishes neuronal hyperexcitability that underlies seizure generation, providing antiepileptic effects without markedly affecting normal neuronal conduction.

The dosage of Lacosamida Tarbis is determined by the prescribing clinician based on the patient’s clinical condition, age, renal function, and concomitant therapies. The prescriber will select an appropriate intravenous dosing regimen and adjust it as needed.

Safety of lacosamide in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should discuss possible exposure with their healthcare provider.

To request Lacosamida Tarbis, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that target fast inactivation. This can provide additive seizure control when combined with other agents, and it may have a lower risk of certain drug‑drug interactions compared with enzyme‑inducing antiepileptics.

Lacosamida Tarbis should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the solution from light and moisture, and keep it out of reach of children. Do not freeze the product.

The product is supplied as an intravenous solution and is administered by slow infusion into a vein under medical supervision. The infusion rate and duration are set by the treating physician according to the patient’s clinical needs.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and emergence of suicidal thoughts or depressive symptoms. Patients should be monitored for these events, especially during treatment initiation or dose changes.

Patients with known hypersensitivity to lacosamide or any component of the formulation should avoid the product. Caution is also advised for individuals with significant cardiac conduction disorders, severe hepatic impairment, or uncontrolled renal disease, where alternative therapies may be preferred.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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