Product image of Lacosamida Tarbis (Lacosamide) supplied by GNH India

Lacosamida Tarbis

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Tarbis (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Tarbis, is a sodium channel blocker presented as an oral formulation for oral use. It is indicated for the treatment of partial‑onset seizures, with or without secondary generalization, and is used as adjunctive therapy in epilepsy management.

GNH India supplies Lacosamida Tarbis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

Lacosamide is an antiepileptic drug that modulates neuronal excitability in seizure disorders.

  • Partial‑onset seizures (with or without secondary generalization): reduces seizure frequency and severity.
  • Adjunctive therapy for epilepsy: added to existing antiepileptic regimens to improve overall seizure control.
  • Focal seizures: enhances control of seizure activity in patients with focal onset epilepsy.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyperexcitable neuronal membranes and decreasing repetitive neuronal firing. This modulation reduces the propagation of epileptiform activity without significantly affecting normal neuronal conduction.

Side Effects

Lacosamide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Fatigue
  • Nausea
  • Headache
  • Diplopia (double vision)
  • Somnolence

Serious or Rare Side Effects

  • Cardiac conduction abnormalities (e.g., PR‑interval prolongation)
  • Suicidal ideation or behavior
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Respiratory depression
  • Anaphylactic or severe hypersensitivity reactions
  • Arrhythmias

Precautions & Warnings

When prescribing Lacosamide, clinicians should consider several safety aspects.

  • Renal impairment: assess renal function and adjust dosing if necessary.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Cardiac conduction disorders: use caution in patients with pre‑existing arrhythmias.
  • Pregnancy: risk category unknown; weigh potential benefits against risks.
  • Discontinuation: avoid abrupt cessation to prevent seizure worsening.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Lacosamide can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide levels.
  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin): may reduce efficacy.
  • Concurrent use with other sodium‑channel blockers: risk of additive cardiac effects.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in contraceptive effectiveness.
  • Antacids containing aluminum or magnesium: may affect absorption.
  • Alcohol: can enhance central nervous system depression.
  • Other antiepileptic drugs: monitor for altered seizure control.
  • Serotonergic agents: observe for signs of serotonin syndrome.

Frequently Asked Questions

Lacosamida Tarbis contains lacosamide, which is prescribed to treat partial‑onset seizures, with or without secondary generalization, and is used as an add‑on therapy for patients with epilepsy who need additional seizure control.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neurons, stabilizing hyper‑excitable membranes and reducing the repetitive firing that leads to seizure activity.

The specific dose and titration schedule are determined by the prescribing clinician based on the individual’s medical condition, response, and tolerability. Patients should follow the prescriber’s instructions exactly.

The pregnancy safety category for lacosamide is not clearly established. It should only be used during pregnancy or lactation if the potential benefit justifies the potential risk, and decisions should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide is a sodium‑channel blocker with a unique mechanism that enhances slow inactivation, differing from many older agents that target fast inactivation. This can provide effective seizure control with a distinct side‑effect profile, making it a valuable option when other medications are insufficient.

Lacosamida Tarbis should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children.

The medication is taken orally, usually as a tablet or capsule, with or without food, as directed by the prescribing physician. Swallow the dose whole with a glass of water.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, suicidal thoughts or behavior, and rare cases of respiratory depression or anaphylaxis. Patients should seek immediate medical attention if any of these occur.

Patients with known hypersensitivity to lacosamide or any component of the formulation should avoid it. Caution is also advised for individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, and those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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