Product image of Lacosamida Vivanta (Lacosamide) supplied by GNH India

Lacosamida Vivanta

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Vivanta (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Vivanta, is an anticonvulsant presented as an intravenous solution for intravenous use. It is indicated for the treatment of partial‑onset seizures and is employed as adjunctive therapy in patients with epilepsy.

GNH India supplies Lacosamida Vivanta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU GMP standards and is sourced from reputable European manufacturers. Its distribution network ensures reliable delivery across multiple continents.

Manufacturer / TM Owner

Vivanta Generics S.R.O.

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Indications & Clinical Uses

  • Lacosamide is used in the management of seizure disorders, particularly focal epilepsy.
  • Partial‑onset seizures: reduces the frequency and severity of seizure episodes when added to existing therapy.
  • Adjunctive therapy for epilepsy: enhances overall seizure control in patients already receiving antiepileptic drugs.
  • Focal epilepsy: provides additional seizure suppression for patients with focal seizure types.

How It Works

  • Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing hyper‑excitable neuronal tissue, it diminishes repetitive firing of action potentials that underlie seizure activity. This modulation of sodium channel kinetics results in a reduction of neuronal excitability without markedly affecting normal conduction, contributing to its antiepileptic efficacy.

Side Effects

Lacosamide may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Nausea
  • Headache
  • Fatigue
  • Blurred vision
  • Somnolence

Serious or Rare Side Effects

  • PR‑interval prolongation or other cardiac arrhythmias
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Respiratory depression
  • Elevated liver enzymes
  • Suicidal thoughts or behavior
  • Anaphylactic reactions

Precautions & Warnings

  • When using Lacosamide, several safety considerations should be observed to minimize risk.
  • Cardiac monitoring: obtain baseline ECG and monitor for PR‑interval prolongation.
  • Renal impairment: adjust dose in patients with severe renal dysfunction.
  • Hepatic dysfunction: monitor liver enzymes during therapy.
  • Discontinuation: taper the dose rather than abrupt cessation to avoid seizure exacerbation.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk, as data are limited.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lacosamide can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Co‑administration with strong CYP3A4 inducers (e.g., carbamazepine) may reduce lacosamide plasma levels.
  • Concurrent use with other sodium‑channel blockers can increase central nervous system depression.
  • Combination with QT‑prolonging agents may heighten the risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives may become less effective; additional contraceptive measures are advised.
  • Use with other antiepileptic drugs may require dose adjustments based on therapeutic response.
  • Alcohol consumption can enhance sedative effects, warranting caution.

Frequently Asked Questions

Lacosamida Vivanta is an intravenous formulation of lacosamide indicated for the treatment of partial‑onset seizures and as adjunctive therapy in patients with epilepsy, helping to reduce seizure frequency when added to existing antiepileptic regimens.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyper‑excitable neurons and decreasing repetitive firing that contributes to seizure generation, thereby providing antiepileptic effects.

The prescribing physician determines the appropriate dose based on individual patient characteristics such as seizure type, concomitant medications, and renal or hepatic function. Dosing regimens are individualized and not publicly standardized.

Safety data are limited. Use in pregnancy only when the potential benefit to the mother outweighs any potential risk to the fetus, and breastfeeding is generally not recommended unless the infant’s need for the drug outweighs the maternal benefit.

Submit an enquiry on the product page at gnhindia.com, providing the required quantity and institutional credentials. GNH India will verify trade eligibility, then respond with pricing, availability, shipping details (including cold‑chain if required) and the necessary import documentation.

Compared with older sodium‑channel blockers such as carbamazepine, lacosamide selectively enhances slow inactivation, offering a distinct safety profile with fewer drug‑interaction concerns, while providing comparable efficacy for focal seizures.

Lacosamida Vivanta must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until it is prepared for intravenous administration.

The medication is given by intravenous infusion under medical supervision. It is typically diluted in a compatible IV fluid and administered over a period defined by the treating physician, following standard aseptic techniques.

Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, respiratory depression, and rare occurrences of suicidal thoughts. Patients should be monitored closely for these signs.

Individuals with known hypersensitivity to lacosamide or its excipients, patients with significant cardiac conduction disorders, and those for whom the risks outweigh the benefits—such as certain pregnant women without a clear indication—should avoid using the drug.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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