Product image of Lacosamida Zentiva (Lacosamide) supplied by GNH India

Lacosamida Zentiva

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Zentiva (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Zentiva, is a Anticonvulsant presented as a oral tablet for Oral use. It treats partial‑onset seizures and epilepsy in patients who require additional seizure control.

GNH India supplies Lacosamida Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers.

Manufacturer / TM Owner

Zentiva Portugal, Lda

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant indicated for seizure disorders and epilepsy.
  • Partial‑onset seizures: Reduces seizure frequency in patients with focal epilepsy.
  • Epilepsy: Provides adjunctive therapy for seizure control in adults with refractory epilepsy.
  • Focal epilepsy: Improves seizure management when added to existing antiepileptic regimens.

How It Works

  • Lacosamide enhances the slow inactivation phase of voltage‑gated sodium channels in neuronal membranes. By stabilizing hyper‑excitable neurons, it reduces the ability of abnormal rapid firing to propagate, thereby decreasing seizure activity. This selective modulation, which does not significantly affect fast inactivation, contributes to its efficacy as an adjunctive treatment for focal seizures.

Side Effects

Lacosamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue
  • Diplopia (double vision)

Serious or Rare Side Effects

  • Suicidal thoughts or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Cardiac conduction abnormalities, including PR‑interval prolongation
  • Hypersensitivity reactions with rash or angioedema

Precautions & Warnings

When prescribing Lacosamide, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: assess kidney function and adjust dose if necessary.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Cardiac conduction: obtain baseline ECG and monitor for PR‑interval prolongation.
  • Pregnancy: safety not established; use only if potential benefit justifies risk.
  • Concomitant antiepileptics: evaluate for additive CNS effects and adjust therapy.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: induces metabolism, reducing lacosamide plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampin, phenytoin): may markedly decrease lacosamide exposure.
  • Co‑administration with other sodium‑channel blockers (e.g., phenytoin, lamotrigine): increases risk of cardiac conduction disturbances.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: lacosamide may lower hormonal efficacy, consider alternative contraception.
  • Antihypertensives: additive hypotensive effect may occur; monitor blood pressure.
  • Valproate or other antiepileptics: potential for altered plasma concentrations; adjust dosing as needed.

Frequently Asked Questions

Lacosamida Zentiva contains lacosamide, an antiepileptic drug used as an adjunctive therapy for the treatment of partial‑onset (focal) seizures in patients with epilepsy who have not achieved adequate control with other medications.

Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This stabilises hyper‑excitable neurons and reduces the ability of abnormal rapid firing to spread, thereby decreasing seizure activity.

The dose of lacosamide is individualized by the prescribing clinician based on the patient’s age, renal function, concomitant therapies and seizure control needs. The prescriber determines the appropriate starting dose and any titration schedule.

Safety of lacosamide in pregnancy and lactation has not been established. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide’s mechanism—enhancing slow sodium‑channel inactivation—differs from many older agents that target fast inactivation. Compared with drugs such as carbamazepine, lacosamide may have a lower risk of certain drug‑enzyme interactions and offers an alternative for patients who do not respond adequately to traditional sodium‑channel blockers.

Store the tablets at room temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat and direct light. Do not store in a refrigerator or freezer.

Lacosamida Zentiva is taken orally, usually with or without food, as directed by the prescribing clinician. Tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious adverse events include suicidal ideation or behaviour, severe skin reactions such as Stevens‑Johnson syndrome, and cardiac conduction abnormalities like PR‑interval prolongation. Patients should be monitored for these events, and any concerning symptoms should be reported to a healthcare professional promptly.

Patients with known hypersensitivity to lacosamide or any excipients in the tablet should avoid the product. Caution is also advised for individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, or those taking interacting medications that could compromise safety.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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