Product image of Lacosamida Viso Farmacéutica (Lacosamide) supplied by GNH India

Lacosamida Viso Farmacéutica

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamida Viso Farmacéutica (Lacosamide)

Lacosamide, the active ingredient in Lacosamida Viso Farmacéutica, is an anticonvulsant presented as a tablet for oral use. It is employed to treat partial‑onset seizures in patients with epilepsy and is indicated as adjunctive therapy when seizures are not adequately controlled by other medications.

GNH India supplies Lacosamida Viso Farmacéutica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets European Union quality standards and is manufactured under GMP conditions. It is distributed through a validated cold‑chain logistics network to ensure product integrity.

Manufacturer / TM Owner

Glenmark Pharmaceuticals S.R.O.

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Indications & Clinical Uses

Lacosamide is used in the management of focal epilepsy, acting as an adjunctive therapy to reduce seizure frequency.

  • Partial-onset seizures: reduces seizure frequency when added to existing antiepileptic regimens.
  • Adjunctive therapy for epilepsy: provides additional seizure control in patients whose seizures are not fully managed by other drugs.
  • Refractory focal epilepsy: may improve seizure control in patients resistant to standard treatments.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyperexcitable neuronal membranes and decreasing repetitive neuronal firing. By selectively targeting the persistent sodium current, it reduces neuronal hyperexcitability without markedly affecting normal conduction, thereby contributing to seizure control in focal epilepsy. This mechanism is distinct from traditional sodium channel blockers that primarily affect fast inactivation, offering a complementary approach when combined with other antiepileptic drugs.

Side Effects

Lacosamide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue

Serious or Rare Side Effects

  • Suicidal thoughts or behavior
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Cardiac conduction abnormalities (e.g., PR interval prolongation)
  • Anaphylactic reactions

Precautions & Warnings

When prescribing lacosamide, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: dose adjustment may be required and renal function should be monitored.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Cardiac conduction: obtain baseline ECG and monitor for PR interval prolongation.
  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus.
  • Concomitant CNS depressants: may increase sedation; monitor patient response.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with other medicines, affecting its plasma levels or increasing adverse effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lacosamide concentrations and risk of toxicity.
  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin, oxcarbazepine): may lower lacosamide levels and reduce efficacy.
  • Other sodium channel blockers (e.g., carbamazepine, phenytoin): may enhance CNS depression and cardiac effects.

Moderate Interactions (Monitor Closely)

  • Concurrent antiepileptic drugs: may require dose adjustments based on therapeutic response.
  • Medications that prolong PR interval (e.g., digoxin, diltiazem): monitor ECG for additive effects.
  • Alcohol: may potentiate central nervous system depression.

Frequently Asked Questions

Lacosamida Viso Farmacéutica contains lacosamide, an anticonvulsant indicated as adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy. It is prescribed when seizure control is insufficient with existing antiepileptic regimens, helping to reduce the frequency of breakthrough seizures.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This stabilises hyperexcitable neurons and reduces repetitive firing, thereby lowering the likelihood of seizure propagation in focal epilepsy. Its selective action on the persistent sodium current distinguishes it from traditional fast‑inactivation blockers.

The dosage of lacosamide is individualized and set by the prescribing healthcare professional. The prescriber determines the appropriate amount based on the patient’s age, weight, renal and hepatic function, concomitant medications, and clinical response, following local prescribing guidelines.

Lacosamide’s pregnancy category is not definitively established. It should be used during pregnancy only when the potential benefit to the mother outweighs any possible risk to the fetus. Limited data are available for breastfeeding; a decision should be made after weighing the infant’s exposure against maternal therapeutic need.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lacosamida Viso Farmacéutica. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with traditional sodium‑channel blockers such as carbamazepine, lacosamide targets the slow inactivation phase of the channel, offering a complementary mechanism that may be better tolerated in some patients. It generally has a lower risk of drug‑induced hyponatremia but shares similar CNS‑depressant potential when combined with other antiepileptics.

Store the product at room temperature, below 25 °C, in its original packaging. Protect it from moisture, excessive heat and direct sunlight. Ensure the container is tightly closed to maintain stability, and keep it out of reach of children.

Lacosamida Viso Farmacéutica is supplied as oral tablets intended for swallowing whole with water. It may be taken with or without food, according to the prescriber’s instructions. Patients should not crush, chew, or split the tablets unless specifically advised.

Serious risks include the potential for suicidal thoughts or behavior, severe skin reactions such as Stevens‑Johnson syndrome, cardiac conduction abnormalities (notably PR‑interval prolongation), and rare anaphylactic reactions. Prompt medical attention is required if any of these events are suspected.

Lacosamide is contraindicated in individuals with known hypersensitivity to lacosamide or any of its excipients. Patients with significant cardiac conduction disorders, such as advanced atrioventricular block without a pacemaker, should avoid its use. Caution is also advised for those with severe renal or hepatic impairment, and it should be prescribed only after careful assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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