Product image of Lacosamide supplied by GNH India

Lacosamide

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide

Lacosamide, the active ingredient in Lacosamide, is an anticonvulsant presented as an oral tablet for oral use. It is indicated for the treatment of partial seizures in patients with epilepsy, helping to reduce seizure frequency.

GNH India supplies Lacosamide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for qualified healthcare providers. The company adheres to stringent quality standards and offers comprehensive regulatory support for global distribution. All batches are manufactured under GMP conditions and undergo rigorous testing to ensure purity and potency.

Manufacturer / TM Owner

Jubilant Pharmaceuticals Nv

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant used to manage seizure disorders.
  • Partial-onset seizures: reduces seizure frequency as adjunctive therapy.
  • Focal epilepsy: helps control focal seizure activity when added to other antiepileptic drugs.
  • Secondary generalization: lowers risk of seizure spread in patients with partial-onset seizures.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and decreasing hyperexcitability. By selectively targeting the slow inactivation phase, it reduces repetitive neuronal firing without affecting normal channel function, thereby diminishing seizure propagation in the central nervous system.

Side Effects

Lacosamide may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: sensation of light‑headedness or imbalance.
  • Nausea: upset stomach or urge to vomit.
  • Headache: mild to moderate pain in the head.
  • Fatigue: feeling unusually tired or weak.
  • Blurred vision: temporary visual disturbances.
  • Diplopia: double vision.

Serious or Rare Side Effects

  • Cardiac conduction abnormalities: PR‑interval prolongation or arrhythmia.
  • Suicidal ideation: thoughts of self‑harm requiring immediate evaluation.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hypersensitivity: rash, itching, or anaphylactic response.
  • Hepatic enzyme elevation: significant increase in liver function tests.
  • Status epilepticus: worsening seizure activity requiring urgent care.

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Renal impairment: adjust dosing and monitor renal function.
  • Hepatic impairment: use caution and monitor liver enzymes.
  • Cardiac conduction disorders: obtain baseline ECG and monitor PR interval.
  • Pregnancy: risk unknown; prescribe only if benefit outweighs potential risk.
  • Concomitant CNS depressants: monitor for enhanced sedation or respiratory depression.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with several medications.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may reduce lacosamide plasma concentrations.
  • Drugs that prolong PR interval (e.g., class IA antiarrhythmics): increase risk of cardiac conduction effects.
  • Other sodium‑channel blockers: may amplify central nervous system adverse effects.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: can increase lacosamide levels, requiring dose adjustment.
  • Phenytoin: may affect metabolism and alter therapeutic response.
  • Alcohol: can enhance dizziness and sedation, necessitating caution.

Frequently Asked Questions

Lacosamide is prescribed as an antiepileptic medication to treat partial‑onset seizures in patients with epilepsy. It is used as an adjunctive therapy to help reduce the frequency and severity of focal seizures when combined with other antiepileptic drugs.

Lacosamide works by enhancing the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This stabilizes the neuronal firing rate, decreasing hyperexcitability and preventing the spread of seizure activity without significantly affecting normal nerve conduction.

The specific dose of Lacosamide is determined by the prescribing clinician based on the patient’s medical condition, age, renal and hepatic function, and response to therapy. Dosage adjustments are individualized and should follow the prescriber’s instructions.

The safety of Lacosamide in pregnancy and lactation has not been fully established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Lacosamide, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide differs from many antiepileptics by selectively enhancing the slow inactivation of sodium channels, which may result in a distinct side‑effect profile and fewer drug‑drug interactions. Clinicians choose it based on seizure type, patient tolerance, and how it complements other medications in a treatment regimen.

Lacosamide should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency throughout its shelf life.

Lacosamide is administered orally, typically in tablet form, and is taken with or without food as directed by the prescribing physician. The exact schedule and dosing frequency are individualized based on the patient’s therapeutic needs.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and potential suicidal thoughts. Patients should be monitored for these events, and any concerning symptoms should prompt immediate medical evaluation.

Lacosamide is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Caution is also advised for patients with significant cardiac conduction disorders, severe renal or hepatic impairment, and those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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