Product image of Lacosamide supplied by GNH India

Lacosamide

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide

Lacosamide, the active ingredient in Lacosamide, is an Anticonvulsant presented as a tablet for oral use. It treats partial‑onset seizures in patients with epilepsy.
GNH India supplies Lacosamide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medley Pharma Limited

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant indicated for seizure disorders.
  • Partial‑onset seizures: reduces seizure frequency when added to existing antiepileptic therapy.
  • Adjunctive therapy for epilepsy: used alongside other antiepileptic drugs to improve overall seizure control.
  • Focal seizures: helps control seizures that originate in a specific brain region.

How It Works

  • Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyper‑excitable neurons and decreasing the likelihood of repetitive firing that precipitates seizure activity.

Side Effects

Lacosamide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: feeling of queasiness or urge to vomit.
  • Headache: mild to moderate cranial pain.
  • Fatigue: unusual tiredness or lack of energy.
  • Visual disturbances: blurred or double vision.
  • Tremor: involuntary shaking of limbs.

Serious or Rare Side Effects

  • Cardiac arrhythmias: including PR‑interval prolongation.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Suicidal thoughts: emergence of depressive or suicidal ideation.
  • Liver injury: abnormal liver function tests or hepatitis.

Precautions & Warnings

  • When prescribing Lacosamide, clinicians should consider several safety and handling precautions.
  • Renal impairment: adjust dose in patients with reduced kidney function.
  • Hepatic impairment: monitor liver function and consider dose modification.
  • Cardiac conduction: avoid in patients with known PR‑interval prolongation or other conduction disorders.
  • Concomitant CNS depressants: may increase sedation when combined.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at ambient temperature: keep below 25°C in original container, protect from moisture.

Avoid Interactions

Lacosamide can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: strong enzyme inducer reduces lacosamide plasma levels.
  • Phenytoin: may lower lacosamide concentrations.
  • Phenobarbital: decreases lacosamide exposure.
  • Rifampin: induces metabolism, lowering efficacy.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): may increase sedation.
  • Alcohol: can enhance central nervous system effects.
  • Other antiepileptics (e.g., valproate): monitor for additive toxicity.
  • QT‑prolonging drugs: monitor cardiac rhythm for potential prolongation.

Frequently Asked Questions

Lacosamide is an antiepileptic medication indicated for the treatment of partial‑onset seizures, also known as focal seizures, and is used as adjunctive therapy in patients with epilepsy who require additional seizure control.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, which stabilizes hyper‑excitable neuronal membranes and reduces the likelihood of repetitive firing that leads to seizures.

The dosage of Lacosamide is individualized; a qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s clinical condition, age, renal function, and concomitant therapies.

The safety of Lacosamide in pregnancy and lactation has not been fully established. Clinicians should assess the potential benefits against possible risks and consider alternative treatments when appropriate.

To request Lacosamide, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older sodium‑channel blockers such as carbamazepine, Lacosamide selectively enhances slow inactivation, which may result in a different side‑effect profile and fewer drug‑interaction concerns, though individual response varies.

Lacosamide should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children.

Lacosamide is taken orally, usually in tablet form, and should be swallowed whole with water. It may be taken with or without food, according to the prescriber’s instructions.

Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and rare cases of suicidal ideation. Patients should be monitored for these signs and seek immediate medical attention if they occur.

Lacosamide is contraindicated in patients with known hypersensitivity to the drug, and it should be used with caution or avoided in individuals with significant cardiac conduction disorders, severe renal impairment, or those taking strong enzyme‑inducing agents that markedly reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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