Product image of Lacosamide Dr. Reddy’s (Lacosamide) supplied by GNH India

Lacosamide Dr. Reddy’s

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Dr. Reddy’s (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Dr. Reddy’s, is an anticonvulsant presented as an injectable solution for intravenous use. It treats partial‑onset seizures and is employed as adjunctive therapy in patients with epilepsy.

GNH India supplies Lacosamide Dr. Reddy’s as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Reddy’s S.R.L.

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Indications & Clinical Uses

  • Lacosamide is used in the management of seizure disorders, specifically targeting partial‑onset seizures in epilepsy.
  • Partial‑onset seizures: reduces seizure frequency as adjunctive therapy.
  • Adjunctive therapy for epilepsy: improves overall seizure control when added to existing regimens.
  • Refractory focal epilepsy: provides an additional option for patients not responding adequately to other antiepileptics.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilises hyperexcitable neuronal membranes and diminishes repetitive neuronal firing. By selectively modulating sodium channel kinetics, it reduces the propagation of epileptiform activity without markedly affecting normal neuronal transmission.

Side Effects

Lacosamide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness: feeling of lightheadedness or unsteadiness.
  • Nausea: mild stomach upset.
  • Fatigue: increased tiredness.
  • Headache: mild to moderate pain.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Respiratory depression: reduced breathing effort.

Precautions & Warnings

  • Lacosamide requires careful monitoring in several clinical situations.
  • Renal impairment: adjust monitoring and consider dose modification.
  • Cardiac conduction disorders: obtain baseline ECG and monitor for PR‑interval changes.
  • Pregnancy: category C, weigh maternal benefits against potential fetal risks.
  • Concomitant CNS depressants: may increase sedation and respiratory effects.
  • Hypersensitivity: discontinue immediately if allergic reaction occurs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lacosamide can interact with other medicines, necessitating vigilance.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may raise lacosamide plasma concentrations.
  • Other sodium‑channel blockers: risk additive cardiac conduction effects.
  • Drugs that prolong PR interval: can cause severe conduction abnormalities.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors: may modestly increase lacosamide levels.
  • Alcohol: can enhance central nervous system depression.
  • Anticoagulants: may affect bleeding risk and require monitoring.

Frequently Asked Questions

Lacosamide Dr. Reddy’s is an injectable anticonvulsant indicated for the treatment of partial‑onset seizures in patients with epilepsy, typically used as adjunctive therapy when additional seizure control is needed.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilising hyperexcitable neuronal membranes and reducing repetitive neuronal firing, which helps to prevent seizure propagation.

The prescribed dose of lacosamide is determined by the treating physician based on the patient’s clinical condition, response, and any relevant laboratory parameters. Dosage adjustments are made individually.

Lacosamide is classified as pregnancy category C, indicating that risk cannot be ruled out. It should only be used if the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding; a risk‑benefit assessment is required.

Enquiries can be submitted on the product page at gnhindia.com by specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that block fast sodium channels or enhance GABA activity. This can offer an alternative for patients who have inadequate response or intolerable side effects with other agents.

Lacosamide Dr. Reddy’s injectable solution must be stored at 2‑8 °C, protected from light, and should not be frozen or shaken. Keep the vial in its original packaging until use.

The medication is given by intravenous injection or infusion under the supervision of a qualified healthcare professional. Administration techniques follow standard aseptic procedures for IV drugs.

Serious risks include cardiac arrhythmias, severe skin reactions such as Stevens‑Johnson syndrome, and respiratory depression. Patients should be monitored for any signs of these events, especially during dose titration.

Lacosamide is contraindicated in patients with known hypersensitivity to the drug or any of its excipients, and in individuals with significant cardiac conduction disorders where PR‑interval prolongation could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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