Product image of Lacosamide Accord (Lacosamide) supplied by GNH India

Lacosamide Accord

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Accord (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Accord, is an anticonvulsant presented as an oral tablet for oral use. It is used as adjunctive therapy for partial‑onset seizures in patients with epilepsy.

GNH India supplies Lacosamide Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Lacosamide is an anticonvulsant indicated for the treatment of focal seizure disorders.

  • Partial‑onset seizures: used as adjunctive therapy to reduce seizure frequency in patients with epilepsy.
  • Focal epilepsy: added to existing regimens to improve seizure control.
  • Adjunctive therapy in epilepsy: enhances overall seizure management when combined with other antiepileptic drugs.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes hyperexcitable neuronal membranes and reduces repetitive neuronal firing associated with seizure activity.

Side Effects

Lacosamide may cause a range of adverse reactions.

Common Side Effects

  • Dizziness
  • Nausea
  • Fatigue
  • Headache

Serious or Rare Side Effects

  • Cardiac conduction abnormalities (e.g., PR‑interval prolongation)
  • Atrial fibrillation
  • Severe skin reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

When prescribing lacosamide, several safety considerations are recommended.

  • Cardiac monitoring: assess ECG for PR‑interval changes, especially in patients with cardiac disease.
  • Renal impairment: adjust dose in patients with reduced kidney function.
  • Hepatic disease: use caution and consider dose modification.
  • Discontinuation: avoid abrupt cessation to reduce risk of seizure recurrence.
  • Suicidal ideation: monitor patients for mood changes.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Lacosamide can interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin, rifampin): may markedly reduce lacosamide plasma levels.
  • Concurrent use with other sodium‑channel blockers: may increase risk of CNS depression.

Moderate Interactions (Monitor Closely):\n- CYP2C19 inhibitors (e.g., fluoxetine, omeprazole): may increase lacosamide exposure.

  • Alcohol: can enhance central nervous system side effects.
  • Anticoagulants (e.g., warfarin): may require monitoring of coagulation parameters.

Frequently Asked Questions

Lacosamide Accord is an anticonvulsant indicated as adjunctive therapy for partial‑onset seizures in patients with epilepsy, helping to reduce seizure frequency when added to existing treatment regimens.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes hyperexcitable neuronal membranes and diminishes the repetitive firing of neurons that underlies seizure activity.

The prescribed dose is individualized by the treating physician based on the patient’s clinical response and tolerability. Specific dosing regimens are determined by the prescriber and are not provided here.

Safety of lacosamide during pregnancy and lactation has not been established. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant.

Submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike many sodium‑channel blockers that affect fast inactivation, lacosamide selectively enhances slow inactivation, offering a distinct mechanism that may provide additional seizure control for patients not fully responsive to other agents.

Store the product at ambient temperature below 25 °C in its original packaging, protected from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged.

Lacosamide Accord is taken orally, typically as a tablet, with or without food, according to the prescribing physician’s instructions.

Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation and atrial fibrillation, as well as severe skin reactions like Stevens‑Johnson syndrome. Patients should be monitored for these signs and seek medical attention if they occur.

Patients with known hypersensitivity to lacosamide or any of its excipients, and those with significant cardiac conduction disorders, should avoid using this medication unless specifically advised by a qualified healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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