Product image of Lacosamide Arrow (Lacosamide) supplied by GNH India

Lacosamide Arrow

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Arrow (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Arrow, is a anti‑epileptic drug presented as a intravenous solution for intravenous use. It treats partial‑onset seizures and is used in status epilepticus.
GNH India supplies Lacosamide Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

Lacosamide is an anti‑epileptic agent used in the management of seizure disorders.

  • Partial‑onset seizures: added to existing therapy to reduce seizure frequency.
  • Status epilepticus: administered intravenously to terminate ongoing seizures.
  • Focal epilepsy: used as adjunctive therapy to improve seizure control.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes hyperexcitable neuronal membranes and reduces repetitive neuronal firing. This modulation of sodium channel activity diminishes the propagation of epileptic discharges without affecting normal neuronal function.

Side Effects

Adverse reactions may occur with lacosamide therapy.

Common Side Effects

  • Dizziness
  • Nausea
  • Headache
  • Fatigue

Serious or Rare Side Effects

  • Cardiac arrhythmia (including PR interval prolongation)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Respiratory depression

Precautions & Warnings

Lacosamide should be used with attention to patient‑specific factors and proper handling.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use caution and consider dose adjustment.
  • Concomitant antiepileptic drugs: assess for altered efficacy or toxicity.
  • Pregnancy: risk unknown; weigh benefits against potential risks.
  • Elderly patients: monitor for dizziness and falls.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lacosamide may interact with other medicines, requiring vigilance.

Major Interactions (Avoid)

  • Carbamazepine, phenytoin, phenobarbital: strong enzyme inducers that may reduce lacosamide levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide exposure.
  • Valproate: may affect plasma concentrations.
  • Beta‑blockers: monitor for additive cardiovascular effects.

Frequently Asked Questions

Lacosamide Arrow is an intravenous formulation of the anti‑epileptic drug lacosamide. It is indicated as adjunctive therapy for partial‑onset (focal) seizures and for the rapid intravenous treatment of status epilepticus in patients who require immediate seizure control.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing these channels, it reduces the ability of neurons to fire repetitively, thereby limiting the spread of epileptic activity without significantly affecting normal neuronal signaling.

The specific dosing regimen for Lacosamide Arrow is determined by the prescribing clinician based on the patient’s condition, age, weight, renal and hepatic function, and concomitant therapies. Healthcare professionals set the appropriate dose and infusion rate for each individual case.

The safety of lacosamide during pregnancy and lactation has not been fully established. Clinicians should evaluate the potential benefits against possible risks to the fetus or infant, and consider alternative therapies when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and required import documentation.

Lacosamide offers a unique mechanism by selectively enhancing slow sodium‑channel inactivation, which can provide seizure control with a different side‑effect profile compared with traditional sodium‑channel blockers such as carbamazepine. Its intravenous formulation allows rapid administration in emergency settings, a feature not shared by many oral antiepileptics.

Lacosamide Arrow should be stored at 2‑8 °C in a refrigerator, protected from light. The solution must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability and sterility.

The product is supplied as a sterile intravenous solution. It is administered by slow infusion through a suitable IV line, following the infusion rate and duration prescribed by the treating physician. Proper aseptic technique and infusion set compatibility should be observed.

Serious adverse events include cardiac arrhythmias such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and respiratory depression. Patients should be monitored for cardiac conduction changes and any signs of hypersensitivity during and after infusion.

Lacosamide Arrow is contraindicated in patients with known hypersensitivity to lacosamide or any component of the formulation. Caution is also advised for individuals with significant cardiac conduction disorders, severe hepatic impairment, or those receiving strong enzyme‑inducing antiepileptic drugs that may markedly reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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