Product image of Lacosamide Aurobindo (Lacosamide) supplied by GNH India

Lacosamide Aurobindo

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Aurobindo (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Aurobindo, is an anticonvulsant presented as an oral tablet for oral use. It treats partial‑onset seizures with or without secondary generalization in adults.

GNH India supplies Lacosamide Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant used as adjunctive therapy for focal seizure disorders.
  • Partial‑onset seizures: reduces seizure frequency when added to existing antiepileptic regimens.
  • Focal seizures with secondary generalization: provides additional seizure control in adults.
  • Adjunctive therapy for epilepsy: improves overall seizure management when combined with other approved agents.

How It Works

  • Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels, stabilizing hyperexcitable neuronal membranes and reducing repetitive neuronal firing that underlies seizure activity. This modulation does not affect the fast inactivation phase, allowing normal neuronal signaling while limiting pathological excitability.

Side Effects

Lacosamide may cause a range of adverse reactions, most of which are mild to moderate in severity.

Common Side Effects

  • Dizziness: transient feeling of light‑headedness.
  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Fatigue: generalized tiredness.
  • Blurred vision: temporary visual disturbance.
  • Somnolence: increased sleepiness.

Serious or Rare Side Effects

  • Cardiac conduction abnormalities: PR‑interval prolongation or arrhythmia.
  • Suicidal ideation: emergence of depressive thoughts.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hypersensitivity: rash, angioedema, or anaphylaxis.
  • Hepatic enzyme elevation: significant increase in liver function tests.
  • Aseptic meningitis: rare inflammatory response of the meninges.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for potential complications.
  • Renal impairment: adjust dose based on creatinine clearance.
  • Hepatic impairment: monitor liver function and consider dose modification.
  • Cardiac conduction disorders: obtain baseline ECG and monitor PR interval.
  • Pregnancy: risk category unknown; discuss potential benefits and risks with the patient.
  • Concomitant CNS depressants: observe for additive sedation or respiratory depression.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide plasma concentrations.
  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin): may reduce lacosamide efficacy.
  • Other sodium‑channel blockers (e.g., lamotrigine, phenytoin): increase risk of cardiac conduction effects.

Moderate Interactions (Monitor Closely)

  • Additional antiepileptic drugs: may require dose adjustments to maintain therapeutic balance.
  • Alcohol or CNS depressants: enhanced sedation or respiratory depression.
  • Hormonal contraceptives: possible reduction in contraceptive effectiveness, consider alternative methods.

Frequently Asked Questions

Lacosamide Aurobindo is an oral anticonvulsant indicated as adjunctive therapy for partial‑onset seizures, with or without secondary generalization, in adult patients with epilepsy. It is prescribed when additional seizure control is needed alongside other antiepileptic medications.

Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing hyperexcitable neurons, it reduces the repetitive firing that contributes to seizure generation while preserving normal neuronal activity.

The dosage of Lacosamide Aurobindo is individualized by the prescribing clinician based on the patient’s clinical condition, prior therapy, renal and hepatic function, and response to treatment. The prescriber determines the appropriate starting dose and titration schedule.

The safety of lacosamide in pregnancy and lactation has not been definitively established. It is classified as pregnancy category unknown, and clinicians should weigh potential benefits against possible risks, discussing options with the patient before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lacosamide differs from many antiepileptics by targeting the slow inactivation phase of sodium channels, offering a distinct mechanism that can be synergistic with drugs acting on fast inactivation or other pathways. This can provide additional seizure control for patients who have not responded adequately to conventional agents.

Lacosamide Aurobindo tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets are swallowed whole with water and should be taken at the same times each day to maintain consistent blood levels.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, rare severe skin reactions (e.g., Stevens‑Johnson syndrome), suicidal thoughts or behavior, and hypersensitivity reactions that may be life‑threatening. Patients should be monitored closely for these events, especially during treatment initiation.

Lacosamide Aurobindo is contraindicated in patients with known hypersensitivity to lacosamide or any of its excipients. Caution is advised for individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, and those taking interacting medications that could markedly alter its plasma levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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