Product image of Lacosamide Crescent (Lacosamide) supplied by GNH India

Lacosamide Crescent

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Crescent (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Crescent, is an anti‑epileptic presented as a tablet for oral use. It treats partial‑onset seizures and is used as adjunctive therapy in epilepsy patients.
GNH India supplies Lacosamide Crescent as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Crescent Pharma Limited

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Indications & Clinical Uses

Lacosamide is an anticonvulsant that acts on neuronal sodium channels to control seizure activity.

  • Partial‑onset seizures: reduces the frequency of focal seizures.
  • Adjunctive therapy for epilepsy: used in combination with other antiepileptic drugs to improve seizure control.
  • Refractory epilepsy: provides additional seizure reduction when standard therapies are insufficient.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing hyper‑excitable neuronal membranes and decreasing repetitive neuronal firing. This modulation reduces neuronal excitability, thereby helping to prevent the initiation and spread of epileptic seizures.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: feeling of stomach upset or urge to vomit.
  • Headache: mild to moderate cranial pain.
  • Fatigue: increased tiredness or lack of energy.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm that may require medical attention.
  • Stevens‑Johnson syndrome: severe skin reaction with blistering and mucosal involvement.

Precautions & Warnings

Before prescribing Lacosamide, consider the following safety measures.

  • Renal impairment: adjust dose and monitor renal function.
  • Hepatic impairment: evaluate liver enzymes and consider dose modification.
  • Cardiac conduction disorders: use caution and monitor ECG.
  • Pregnancy: risk unknown; weigh potential benefits against risks.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Lacosamide can interact with several medicines; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Carbamazepine: may significantly lower lacosamide plasma levels.
  • Phenytoin: can reduce lacosamide exposure.
  • Rifampin: induces metabolism, decreasing lacosamide effectiveness.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): may increase sedation.
  • Alcohol: can enhance dizziness and drowsiness.

Frequently Asked Questions

Lacosamide Crescent is used to treat partial‑onset (focal) seizures and is prescribed as an add‑on therapy for patients with epilepsy who need additional seizure control beyond their current medication regimen.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neurons, which stabilizes hyper‑excitable membranes and reduces the likelihood of repetitive firing that leads to seizures.

The specific dose and titration schedule are determined by the prescribing clinician based on the patient’s age, weight, renal function, and response to therapy. Patients should follow the prescriber’s instructions exactly.

The safety of lacosamide in pregnancy and lactation has not been fully established. Healthcare providers must weigh potential benefits against possible risks and discuss options with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—differs from many traditional antiepileptics that target fast inactivation. This can provide complementary seizure control when combined with other agents, and it is generally well tolerated compared with some older drugs that have broader side‑effect profiles.

Lacosamide Crescent should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

The medication is taken orally, usually as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water and follow the dosing schedule provided by the healthcare professional.

Serious risks include cardiac arrhythmias, especially in patients with pre‑existing conduction disorders, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience chest pain, irregular heartbeat, or extensive rash.

Patients with known hypersensitivity to lacosamide or any of its excipients should avoid the drug. Caution is also advised for individuals with significant cardiac conduction abnormalities, severe renal or hepatic impairment, unless a prescriber determines the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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