Product image of Lacosamide Fresenius Kabi (Lacosamide) supplied by GNH India

Lacosamide Fresenius Kabi

Active Ingredient:
Lacosamide
Origin:
EU

Lacosamide Fresenius Kabi (Lacosamide)

Lacosamide, the active ingredient in Lacosamide Fresenius Kabi, is an anticonvulsant presented as an intravenous solution for intravenous use. It is indicated for the treatment of partial‑onset seizures in patients with epilepsy, helping to control seizure activity and improve neurological stability.

GNH India supplies Lacosamide Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to this essential antiepileptic medication. The product complies with European Union regulatory standards and is manufactured under strict quality controls.

Manufacturer / TM Owner

Fresenius Kabi Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Lacosamide is an anticonvulsant used in the management of seizure disorders.
  • Partial‑onset seizures (focal seizures): reduces seizure frequency as adjunctive therapy in epilepsy patients.
  • Epilepsy (focal epilepsy): provides additional seizure control when added to existing antiepileptic regimens.
  • Refractory epilepsy: offers an alternative mechanism of action for patients whose seizures are not adequately controlled by other medications.

How It Works

  • Lacosamide selectively enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. By stabilizing the inactive state of these channels, it reduces neuronal hyperexcitability and limits the propagation of abnormal electrical activity that underlies seizure generation.

Side Effects

Lacosamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Fatigue
  • Diplopia (double vision)
  • Somnolence

Serious or Rare Side Effects

  • Cardiac conduction abnormalities (e.g., PR interval prolongation, atrial fibrillation)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Suicidal ideation or behavior
  • Respiratory depression
  • Significant hepatic enzyme elevations
  • Allergic reactions including anaphylaxis

Precautions & Warnings

  • When using Lacosamide, clinicians should consider several safety aspects.
  • Renal impairment: adjust monitoring as the drug is primarily excreted unchanged by the kidneys.
  • Hepatic impairment: use caution and monitor liver function tests regularly.
  • Cardiac conduction disorders: obtain baseline ECG and monitor for PR‑interval changes.
  • Pregnancy: prescribe only if the potential benefit justifies the potential risk to the fetus.
  • Concomitant CNS depressants: may increase sedation and respiratory depression.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Lacosamide can interact with other medicines, affecting its safety or efficacy.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine): may exacerbate PR‑interval prolongation.
  • Carbamazepine: can reduce lacosamide plasma concentrations.
  • Other sodium‑channel blockers (e.g., phenytoin, lamotrigine): additive effects on cardiac conduction.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluconazole): may increase lacosamide exposure.
  • CNS depressants (e.g., benzodiazepines): may enhance sedation.
  • Diuretics: may affect renal clearance of lacosamide.

Frequently Asked Questions

Lacosamide Fresenius Kabi is an intravenous antiepileptic medication indicated for the treatment of partial‑onset (focal) seizures in patients with epilepsy. It is used as an adjunctive therapy to help reduce seizure frequency and improve overall seizure control.

Lacosamide works by selectively enhancing the slow inactivation of voltage‑gated sodium channels in neurons. This stabilizes the neuronal membrane, reduces hyperexcitability, and limits the spread of abnormal electrical activity that can trigger seizures.

The dosage of lacosamide is individualized and set by the prescribing clinician based on the patient’s condition, age, renal function, and response to therapy. Specific dosing regimens are not provided here and should be obtained from a qualified healthcare professional.

Safety data for lacosamide in pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians should discuss risks and alternatives with the patient.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and import documentation.

Lacosamide has a unique mechanism that enhances slow sodium‑channel inactivation, differing from many other antiepileptics that block fast sodium channels or modulate GABA. This can provide an alternative option for patients who have inadequate response or intolerance to other agents.

Lacosamide intravenous solution should be stored at 2‑8 °C (refrigerated). Keep the product in its original container, protect it from light, and avoid freezing or shaking to maintain stability and potency.

Lacosamide is administered by intravenous infusion under the supervision of a qualified healthcare professional. The infusion rate and duration are determined by the prescriber and may be adjusted based on patient response and tolerability.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation or atrial fibrillation, severe skin reactions like Stevens‑Johnson syndrome, and rare cases of suicidal ideation. Patients should be monitored closely for these events, especially during treatment initiation.

Lacosamide is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is advised for individuals with significant cardiac conduction disorders, severe renal impairment, or those taking interacting medications that may increase the risk of adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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